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- Table of Contents
Facts about Transient receptor potential cation channel subfamily V member 1.
Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
Human | |
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Gene Name: | TRPV1 |
Uniprot: | Q8NER1 |
Entrez: | 7442 |
Belongs to: |
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transient receptor (TC 1.A.4) family |
Capsaicin Receptor; Osm-9-like TRP channel 1; OTRPC1; transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TRPV1; Vanilloid R1; Vanilloid receptor 1; vanilloid receptor subtype 1; VanilloidR1; VR1; VR1DKFZp434K0220
Mass (kDA):
94.956 kDA
Human | |
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Location: | 17p13.2 |
Sequence: | 17; NC_000017.11 (3565446..3609411, complement) |
Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Mostly, but not exclusively expressed in postsynaptic dendritic spines.
PMID: 11050376 by Hayes P., et al. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.
PMID: 11243859 by Cortright D.N., et al. The tissue distribution and functional characterization of human VR1.