This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
VRK2 Antibodies
AND VRK2 ELISA kits, VRK2 Proteins
Many biological assays use antibodies to detect VRK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VRK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VRK2 antibodies...
Previous: CBLIF
Next: VSNL1
VRK2 Infographic by Boster Bio
All VRK2 Products
Product
Figures
Specificity
Applications
Price
VRK2 Overview
Facts about Serine/threonine-protein kinase VRK2.
Serine/threonine-protein kinase VRK2 (VRK2)
Serine/threonine kinase that modulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this depends on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes.
Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates'Thr-18' of p53/TP53, histone H3, and might also phosphorylate MAPK8IP1.
Gene Information
| Human | |
|---|---|
| Gene Name: | VRK2 |
| Uniprot: | Q86Y07 |
| Entrez: | 7444 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; serine/threonine-protein kinase VRK2; vaccinia related kinase 2; vaccinia virus B1R-related kinase 2; Vaccinia-related kinase 2; vaccinia-related kinase-2
Molecular Weight
Mass (kDA):
58.141 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p16.1 |
| Sequence: | 2; NC_000002.12 (57907651..58163993) |
Tissue Specificity
Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein. Nucleus envelope.; [Isoform 2]: Cytoplasm. Nucleus.
Diseases
- Vaccinia
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Schizophrenia
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Epilepsy, Generalized
- Ataxia
- Craniofacial Abnormalities
- Colonic Neoplasms
- Glaucoma, Open-angle
- Hypoxia
Interacting Proteins
- KSR1
- Ksr1
- MAP2K1
- Map3k7
- NFATC2
- Nfatc2
- RAN
- Tab1
Pathways
- Localization
- Cell Cycle
- Cell Proliferation
- Dna Replication
- Protein Phosphorylation
- Hyperphosphorylation
- Membrane Organization
- Spermatogenesis
- Cell Division
- Translation
- Cell Communication
- Oogenesis
- Signal Transmission
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VRK2
bosterbio.com/bosterbio-gene-info-cards/VRK2
References
PMID: 9344656 by Nezu J., et al. Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to Vaccinia virus B1R kinase.
PMID: 16704422 by Blanco S., et al. The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.