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- Table of Contents
Facts about E3 ubiquitin-protein ligase TRIM50.
Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. .
Human | |
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Gene Name: | TRIM50 |
Uniprot: | Q86XT4 |
Entrez: | 135892 |
Belongs to: |
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TRIM/RBCC family |
tripartite motif containing 50; tripartite motif protein 50; tripartite motif-containing 50A; tripartite motif-containing protein 50
Mass (kDA):
54.774 kDA
Human | |
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Location: | 7q11.23 |
Sequence: | 7; NC_000007.14 (73312536..73328082, complement) |
Cytoplasm. Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins.
PMID: 18398435 by Micale L., et al. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.
PMID: 22792322 by Fusco C., et al. The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.