TRIM5 Antibodies

AND TRIM5 ELISA kits, TRIM5 Proteins

Many biological assays use antibodies to detect TRIM5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM5 antibodies...

We validate the specificity of these antibodies to TRIM5 by testing them on tissues known to express TRIM5 positively and negatively. Browse below to find the TRIM5 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRIM5 Infographic by Boster Bio

All TRIM5 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TRIM5 Antibody Picoband®

5 Q&As

Human

ELISA, WB

$370
Cat # A01359-1
100 μg/vial

Anti-TRIM5 gamma Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A01359
0.1 mg

Anti-TRIM5 Antibody

Human, Mouse

$405
Cat # A01359-2
100ul

Anti-TRIM alpha TRIM5 Monoclonal Antibody

Human

ELISA, IHC, WB

$380
Cat # M01359
100ul

TRIM5 alpha (TRIM5) (NM_033034) Human Over-expression Lysate

Human

$960
Cat # LS085363
100 µg

TRIM5 Overview

Facts about Tripartite motif-containing protein 5.

TRIM5 3D structure. Source: alphafold

Tripartite motif-containing protein 5 (TRIM5)

Capsid-specific restriction factor that prevents disease from non-host-adapted retroviruses. Blocks viral replication early in the life span, after viral entry but before reverse transcription.

In addition to acting as a capsid-specific restriction factor, also functions as a pattern recognition receptor which triggers innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates'Lys-63'-linked polyubiquitin chains, which then are catalysts in the autophosphorylation of the MAP3K7/TAK1 complicated (contains TAK1, TAB2, and TAB3).

Gene Information

Human
Gene Name:	TRIM5
Uniprot:	Q9C035
Entrez:	85363

Family

Belongs to:

TRIM/RBCC family

Alternative Names

EC 6.3.2; EC 6.3.2.-; RING finger protein 88; RNF88tripartite motif protein TRIM; TRIM5alpha; tripartite motif containing 5; tripartite motif protein TRIM5; tripartite motif-containing 5; tripartite motif-containing protein 5

Molecular Weight

Mass (kDA):
56.338 kDA

Genomic Context


Human

Location:	11p15.4
Sequence:	11; NC_000011.10 (5590906..5685108, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Predominantly localizes in cytoplasmic bodies (PubMed:12878161, PubMed:20357094). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (By similarity). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (By similarity).