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- Table of Contents
Facts about Tribbles homolog 3.
Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases.
Human | |
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Gene Name: | TRIB3 |
Uniprot: | Q96RU7 |
Entrez: | 57761 |
Belongs to: |
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protein kinase superfamily |
C20orf97; dJ1103G7.3; neuronal cell death inducible putative kinase; Neuronal cell death-inducible putative kinase; NIPK; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; SINK; SKIP3; TRB-3; TRB3chromosome 20 open reading frame 97; tribbles homolog 3 (Drosophila); tribbles homolog 3
Mass (kDA):
39.578 kDA
Human | |
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Location: | 20p13 |
Sequence: | 20; NC_000020.11 (380629..397559) |
Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.
Nucleus.
PMID: 12743605 by Bowers A.J., et al. SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.
PMID: 12736262 by Wu M., et al. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.