TREML2 Antibodies

Trem-like transcript 2 protein (TREML2)

Cell surface receptor that may play a role in the innate and adaptive immune reaction. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enriches T-cell activation.

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Gene Information

Human
Gene Name:	TREML2
Uniprot:	Q5T2D2
Entrez:	79865

Family

Belongs to:
No superfamily

Alternative Names

C6orf76; dJ238O23.1; FLJ13693; MGC149715; MGC149716; TLT2; TLT-2; TREML2; trem-like transcript 2 protein; triggering receptor expressed on myeloid cells-like 2; triggering receptor expressed on myeloid cells-like protein 2; UNQ6268/PRO20473

Molecular Weight

Mass (kDA):
35.127 kDA

Genomic Context

Human
Location:	6p21.1
Sequence:	6; NC_000006.12 (41189749..41201233, complement)

Tissue Specificity

Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Inflammation
• Sclerosis
• Periodontitis
• Osteopenia
• Inflammatory Bowel Diseases
• Multiple Sclerosis
• Tissue Adhesions
• Autoimmune Diseases
• Intestinal Diseases
• Contact Dermatitis
• Arthritis
• Malignant Neoplasms

• Neoplasms
• Innate Immune Response
• Bacterial Infections
• Rheumatoid Arthritis
• Contact Hypersensitivity
• Tissue Damage

Pathways

• Immune Response
• Osteoclast Differentiation
• Cell Activation
• Cytokine Production
• Cell Development
• T Cell Activation
• Innate Immune Response
• Bone Remodeling

• Hypersensitivity
• Bone Resorption

PTMs

• Disulfide bond

• Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TREML2

Best Uses Of The TREML2 Marker For Research

This article outlines the most effective uses of the TREML2 indicator for research. You can also learn about Boster primary antibodies, which are widely cited in research. These antibodies have been validated using Western Blotting, Immunohistochemistry, and ELISA. These antibodies are made in the USA and are safe for research. Boster is the right choice for researchers who are looking for a reliable marker.

Researchers trust Boster’s primary antibodies.

Boster Bio produces high-quality primary antibodies, ELISA kits, and other reagents. These products have undergone rigorous validation and testing across multiple matrices, including mouse as well as human. Boster has been supplying researchers with high-quality antibodies, detection kits, and other products since 1993. Our products are suitable for a wide range of applications including IHC, ELISA and WB.

Boster primary antibodies are often used in scientific research, due to their high affinity. These antibodies are highly cited and trusted by the research community. Boster's antibodies can also be validated by Western Blotting, which confirms their efficacy and quality. Research communities have trusted our primary antibodies over 25-years. You can trust our products' high quality and enjoy our exceptional service and guarantee.

To ensure product safety, we conduct extensive QC/QA inspections as part our quality assurance commitment. In order to ensure high-quality products, we carefully analyze citation data from research journals to validate the antibodies we produce. We also have strict quality control in all our processes, even the production of secondary antibody. We only use the highest quality, purified antibodies to meet these high standards.

Rockland produces an extensive range of primary antibody that can be used to perform a variety of research tasks due to their high affinity. These antibodies are capable of detecting target antigens with high specificity as well as affinity. They can also have secondary antibodies removed by conjugation. Rockland's antibodies are excellent for immunoblotting as well as other immunological applications due to their versatility.

Boster's antibodies can be found all over the world.

Biosimilar antibodies are an important component of cancer treatment. Their use in diagnosis and screening is critical. Surge in cases of autoimmune diseases has increased the demand for biosimilar antibodies. Many pharmaceutical companies have decided to concentrate on developing biosimilar antibodies rather than traditional blockbuster drugs due to the increased demand for them. Although product development and launch remain a top priority for manufacturers biosimilars are becoming cheaper and will likely grow faster than blockbuster medicines. Biosimilar antibodies are the fastest growing segment of the market. Growth is expected to occur in the U.S. as well as India and China. This is due to the increasing demand for biosimilar antibody, which are less expensive than blockbuster drugs.

TREML2 a reliable marker

The first study examining TREML2's role in Alzheimer's disease focuses exclusively on a particular gene, rs3747742. The research team looked at the effects of TREML2 on CSF protein, cognitive function, and other neuroimaging biomarkers. This study is part of a larger initiative, ADNI, to study the role of genetic variants in Alzheimer's disease.

Researchers have shown that the rs3747742 variant of TREML2 has a significant impact on cognitive function. This variant has been found to be associated with cerebral cortices as well as the hippocampus and hippocampus subfields. Further, intracranial volume has been linked with rs3747742. The results were consistent but not perfect.

TREML2 is a new gene that has been linked to Alzheimer's disease. One missense variant, rs3747742-C, reduced AD risk in Han Chinese and Caucasians. It is believed that TREML2 influences brain structure and has been linked to the development of AD. The ADNI database includes information on 158 cognitively-normal elders, as well complete data on brain structure.

Boster's antibodies were manufactured in the United States

Both light and heavy chains are made up of two types of amino compounds: the constant (CL), as well as the variable (VL), domains. These two types have 110 amino acid each. Both heavy and light chains have one variable domain, and three to four constant domains. The only place where there is any variation in amino acids sequences is at the one end of the domains. The variable domains, by contrast, are relatively constant and only show a few changes in amino acids.

Monoclonal antibody are made in China from cells taken from the Chinese hamster egg. They are grown in bioreactors and purified before being packaged for administration. This process is complex and requires expensive materials. A single antibody can cost as much as $95 to $200, not including research and development. The costs increase significantly with smaller quantities and start-up companies.

The basic structure for an antibody molecule is four polypeptide chain: two light and two heavy chains. These chains are joined by covalent as well as noncovalent bond. The heavy chains are those that bind to antigens. The different heavy chains make up the tail (Fc), which determines which proteins bind to the antigen. The different classes are distinguished because of their unique properties.

Antibodies are essentially the product of an immune response. They bind to and neutralize antigens. We must first understand how the body works to understand how the immune systems recognize antigens. Each B cell has around 105 receptors found in its plasma membrane. These receptors are closely linked to intracellular signaling pathways. There are differences between light- and heavy chains.