TREM2 Antibodies

AND TREM2 ELISA kits, TREM2 Proteins

Many biological assays use antibodies to detect TREM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TREM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TREM2 antibodies...

We validate the specificity of these antibodies to TREM2 by testing them on tissues known to express TREM2 positively and negatively. Browse below to find the TREM2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TREM2 Infographic by Boster Bio

All TREM2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human TREM2 ELISA Kit PicoKine®

9 Q&As

Human

ELISA

$499
Cat # EK1678
96 wells/kit, with removable strips.

Anti-TREM2 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A02150
100ul

Anti-Trem2 Antibody Picoband®

Rat

ELISA, Flow Cytometry, WB

$370
Cat # A02150-3
100 μg/vial

Human TREM-2 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9NZC2
Starting from 10ug

TREM2 Overview

Facts about Triggering receptor expressed on myeloid cells 2.

TREM2 3D structure. Source: alphafold

Triggering receptor expressed on myeloid cells 2 (TREM2)

Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.

Gene Information

Human
Gene Name:	TREM2
Uniprot:	Q9NZC2
Entrez:	54209

Family

Belongs to:

No superfamily

Alternative Names

PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2triggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2

Molecular Weight

Mass (kDA):
25.447 kDA

Genomic Context


Human

Location:	6p21.1
Sequence:	6; NC_000006.12 (41158508..41163116, complement)

Tissue Specificity

Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.

Diseases

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Dementia
Bone Cysts
Inflammation
Presenile Dementia
Leukoencephalopathies
Nerve Degeneration
Alzheimer's Disease
Nervousness
Inflammatory Response
Hereditary Diseases
Autoimmune Reaction

Subacute Sclerosing Panencephalitis
Osteochondrodysplasias
Multiple Sclerosis
Lipodystrophy
Osteopenia
Sclerosis
Chronic Inflammation

Interacting Proteins

APOE
APP
PSEN1
TYROBP

Pathways

Phagocytosis
Immune Response
Inflammatory Response
Pathogenesis
Osteoclast Differentiation
Bone Resorption
Cell Activation
Secretion
Osteoclast Development
Innate Immune Response
Cytokine Production
Chemotaxis
Macrophage Activation

Tissue Homeostasis
Neutrophil Degranulation
Myelination
Cell Maturation
System Development
Translation
Axon Guidance

PTMs

Phosphorylation
Biotinylation

Acetylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TREM2

References

PMID: 10799849 by Bouchon A., et al. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.

PMID: 11602640 by Bouchon A., et al. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.