TRA2B Antibodies

AND TRA2B ELISA kits, TRA2B Proteins

Many biological assays use antibodies to detect TRA2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRA2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRA2B antibodies...

We validate the specificity of these antibodies to TRA2B by testing them on tissues known to express TRA2B positively and negatively. Browse below to find the TRA2B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRA2B Infographic by Boster Bio

All TRA2B Products

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TRA2B (NM_004593) Human Recombinant Protein

$1062
Cat # PROTP62995
20 µg

TRA2B (NM_004593) Human Over-expression Lysate

Human

$628
Cat # LS006434
100 µg

TRA2B Overview

Facts about Transformer-2 protein homolog beta.

TRA2B 3D structure. Source: alphafold

Transformer-2 protein homolog beta (TRA2B)

Sequence-specific RNA-binding protein that participates in the control of pre-mRNA splicing. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2.

Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX.

Gene Information

Human
Gene Name:	TRA2B
Uniprot:	P62995
Entrez:	6434

Family

Belongs to:

splicing factor SR family

Alternative Names

DKFZp686F18120; Htra2-beta; SFRS10; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); Splicing factor, arginine/serine-rich 10; SRFS10; TRA-2 beta; TRA2-BETA; TRAN2B; transformer 2 beta homolog (Drosophila); transformer 2 homolog; Transformer-2 protein homolog B; transformer-2 protein homolog beta; transformer-2-beta

Molecular Weight

Mass (kDA):
33.666 kDA

Genomic Context


Human

Location:	3q27.2
Sequence:	3; NC_000003.12 (185914558..185938027, complement)

Tissue Specificity

Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.

Subcellular Localizations

Nucleus.

Diseases

Spinal Muscular Atrophy
Atrophy
Muscular Atrophy
Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Brain Ischemia
Ischemia
Infarction
Tumor Progression
Neurodegenerative Disorders
Motor Neuron Disease
Neuroblastoma

Obesity
Metastatic Malignant Neoplasm To The Lymph Node
Malignant Neoplasm Of Breast
Dementia
Hypoxia
Neoplasm Invasiveness
Malignant Tumor Of Cervix

Interacting Proteins

CLK3
RBMX
RBMY1F
SRPK2
SRSF4

YTHDC1

Pathways

Localization
Mrna Splicing
Mrna Processing
Rna Splicing
Cell Death
Rna Processing
Pathogenesis
Smooth Muscle Cell Proliferation
Hyperphosphorylation
Muscle Cell Proliferation
Cell Proliferation
Brain Development
Regulation Of Gene Expression

Sex Determination
Energy Homeostasis
Spermatogenesis
Response To Ischemia
Neuroprotection
Regeneration
Sex Differentiation

PTMs

Cleavage

Phosphorylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRA2B

References

PMID: 9212162 by Beil B., et al. Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing.

PMID: 9790768 by Nayler O., et al. Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform.