TP53RK Antibodies

AND TP53RK ELISA kits, TP53RK Proteins

Many biological assays use antibodies to detect TP53RK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TP53RK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TP53RK antibodies...

We validate the specificity of these antibodies to TP53RK by testing them on tissues known to express TP53RK positively and negatively. Browse below to find the TP53RK antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TP53RK Infographic by Boster Bio

All TP53RK Products

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Product

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Specificity

Applications

Price

Anti-TP53RK Antibody

Human, Mouse, Rat

$405
Cat # A09786
100ul

Anti-PRPK (TP53RK) Mouse Monoclonal Antibody [Clone ID: OTI5B2]

Human, Mouse, Rat

IHC, WB

$523
Cat # M09786
100 µl

PRPK (TP53RK) (NM_033550) Human Over-expression Lysate

Human

$628
Cat # LS112858
100 µg

TP53RK Overview

Facts about EKC/KEOPS complex subunit TP53RK.

TP53RK 3D structure. Source: alphafold

EKC/KEOPS complex subunit TP53RK (TP53RK)

Part of the EKC/KEOPS complex that's necessary for the creation of a threonylcarbamoyl set on adenosine at position 37 (t(6)A37) in tRNAs that read codons starting with adenine (PubMed:22912744, PubMed:27903914). The complex is likely involved in the transfer of this threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 set of A37 (PubMed:22912744, PubMed:27903914).

TP53RK has ATPase activity in the context of this EKC/KEOPS complex and probably plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).

Gene Information

Human
Gene Name:	TP53RK
Uniprot:	Q96S44
Entrez:	112858

Family

Belongs to:

protein kinase superfamily

Alternative Names

BUD32; C20orf64; chromosome 20 open reading frame 64; dJ101A2; dJ101A2.2; EC 2.7.11.1; Nori-2; Nori-2p; p53-related protein kinase; prpk; TP53 regulating kinase; TP53-regulating kinase

Molecular Weight

Mass (kDA):
28.16 kDA

Genomic Context


Human

Location:	20q13.12
Sequence:	20; NC_000020.11 (46684365..46689444, complement)

Tissue Specificity

Highly expressed in testis. Weakly expressed in heart kidney and spleen.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Adenocarcinoma
Cell Transformation, Neoplastic
Neoplasm Metastasis
Epithelioma
Malignant Neoplasm Of Breast
Bone Neoplasms
Osteosarcoma

Encephalopathies
Retinoblastoma
Colorectal Neoplasms
Mammary Neoplasms

Interacting Proteins

CALCOCO2
MTUS2
OSGEP
TPRKB

Pathways

Cell Cycle
Mitosis
Pathogenesis
Rna Interference
Localization

PTMs

Phosphorylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TP53RK

References

PMID: 11546806 by Abe Y., et al. Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.

PMID: 12659830 by Miyoshi A., et al. Identification of CGI-121, a novel PRPK (p53-related protein kinase)- binding protein.