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TP53 Antibodies
AND TP53 ELISA kits, TP53 Proteins
Many biological assays use antibodies to detect TP53, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TP53 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TP53 antibodies...
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TP53 Infographic by Boster Bio
All TP53 Products
Product
Figures
Specificity
Applications
Price
Anti-P Glycoprotein/ABCB1 Antibody
32 Citations 4 Q&As
Human, Mouse, Rat
IHC
$370
Cat # RP1034
100 μg/vial
Cat # RP1034
100 μg/vial
Human P53 ELISA Kit PicoKine®
11 Citations 9 Q&As
Human
ELISA
$499
Cat # EK0895
96 wells/kit, with removable strips.
Cat # EK0895
96 wells/kit, with removable strips.
Anti-P53 Tp53 Monoclonal Antibody
51 Citations 4 Q&As
Human
IHC, ICC, WB
$370
Cat # MA1078
100 μg/vial
Cat # MA1078
100 μg/vial
Anti-P53/TP53 Antibody Picoband®
71 Citations 6 Q&As
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9008
100 μg/vial
Cat # PB9008
100 μg/vial
Anti-Phospho-p53 (S9) TP53 Rabbit Monoclonal Antibody
7 Citations 3 Q&As
Human
WB
$370
Cat # P00001-3
100 μl
Cat # P00001-3
100 μl
Anti-Phospho-p53 (S33) TP53 Rabbit Monoclonal Antibody
7 Citations 4 Q&As
Human
IF, ICC, WB
$370
Cat # P00001-4
100 μl
Cat # P00001-4
100 μl
Anti-Phospho-p53 (T55) TP53 Rabbit Monoclonal Antibody
7 Citations 3 Q&As
Human
WB
$370
Cat # P00001-5
100 μl
Cat # P00001-5
100 μl
Anti-Phospho-p53 (S392) TP53 Rabbit Monoclonal Antibody
15 Citations 4 Q&As
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # P00001-6
100 μl
Cat # P00001-6
100 μl
Anti-p53 TP53 Rabbit Monoclonal Antibody
11 Citations 4 Q&As
Human
IP, IF, IHC, ICC, WB
$370
Cat # M00001-1
100 μl
Cat # M00001-1
100 μl
Anti-p53 TP53 Rabbit Monoclonal Antibody
10 Citations 5 Q&As
Human
IF, ICC, WB
$370
Cat # M00001-2
100 μl
Cat # M00001-2
100 μl
Anti-Mutant p53 Rabbit Monoclonal Antibody
9 Citations 17 Q&As
Human
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M00001-3
100 μl
Cat # M00001-3
100 μl
Anti-p53 (acetyl K370) TP53 Rabbit Monoclonal Antibody
17 Citations 16 Q&As
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # P00001-1
100 μl
Cat # P00001-1
100 μl
Anti-p53 (acetyl K382) TP53 Rabbit Monoclonal Antibody
9 Citations 16 Q&As
Human
IF, IHC, ICC, WB
$370
Cat # P00001-2
100 μl
Cat # P00001-2
100 μl
Anti-p53 Monoclonal Antibody (PAb122)
18 Citations 16 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IHC, ICC, WB
$674
Cat # M00001-4
200µg
Cat # M00001-4
200µg
Human, Mouse, Rat
ELISA
$480
Cat # EKC1426
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1426
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2095
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2095
1 kit, containing two 96-well plates and all necessary reagents
Human, Rat
ELISA
$540
Cat # EKC2486
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2486
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2487
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2487
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00001S20-1
100ul
Cat # A00001S20-1
100ul
Human, Monkey, Mouse
Flow Cytometry, IF, IHC, WB
$523
Cat # M00001-5
100 µl
Cat # M00001-5
100 µl
TP53 Overview
Facts about Cellular tumor antigen p53.
Cellular tumor antigen p53 (TP53)
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this procedure.
One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Gene Information
| Human | |
|---|---|
| Gene Name: | TP53 |
| Uniprot: | P04637 |
| Entrez: | 7157 |
Family
| Belongs to: |
|---|
| p53 family |
Alternative Names
Antigen NY-CO-13; BCC7; FLJ92943; LFS1; LFS1TRP53; p53 tumor suppressor; p53; P53cellular tumor antigen p53; Phosphoprotein p53; TP53; transformation-related protein 53; TRP53; tumor protein p53; Tumor suppressor p53
Molecular Weight
Mass (kDA):
43.653 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7668402..7687550, complement) |
Tissue Specificity
Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Interaction with BANP promotes nuclear localization (PubMed:15701641). Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408).; [Isoform 1]: Nucleus. Cytoplasm. Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; [Isoform 2]: Nucleus. Cytoplasm. Local
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Carcinogenesis
- Malignant Squamous Cell Neoplasm
- Leukemia
- Neoplasm Metastasis
- Lung Neoplasms
Pathways
- Cell Cycle
- Cell Death
- Pathogenesis
- Cell Proliferation
- Cell Cycle Arrest
- Methylation
- Dna Repair
- Cell Growth
- Senescence
- Localization
- Induction Of Apoptosis
- Angiogenesis
- Mismatch Repair
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Ubiquitination
- Deacetylation
- Dephosphorylation
- Demethylation
- Reduction
- Oxidation
Research Areas
- Apoptosis
- Cancer
- Cell Cycle and Replication
- Checkpoint signaling
- Core ESC-Like Genes
- DNA Double Strand Break Repair
- DNA Repair
- Hypoxia
- p53 Pathway
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TP53
bosterbio.com/bosterbio-gene-info-cards/TP53
References
PMID: 4006916 by Zakut-Houri R., et al. Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.
PMID: 2946935 by Lamb P., et al. Characterization of the human p53 gene.
89 Publications of Boster TP53 Antibodies & ELISA Kits
- PubMed ID: 10.7150/ijms.47360, Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical ...
- PubMed ID: 10.5483/BMBRep.2008.41.10.745, P53 transcription-independent activity mediates selenite-induced acute promyeloc...
- PubMed ID: 10.3892/or.2015.4395, Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung c...
- PubMed ID: 10.3892/or.16.5.1021, Histological type of oncogenity and expression of cell cycle genes in tumor cell...
- PubMed ID: 10.3748/wjg.14.5008, Positional and expressive alteration of prohibitin during the induced differenti...
- PubMed ID: 10.3390/md15020039, Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer
- PubMed ID: 10.1371/journal.pone.0151060, Expression of Heat Shock Protein 70 Gene and Its Correlation with Inflammatory M...
- PubMed ID: 10.1155/2021/5594059, Ferritinophagy-Mediated ROS Production Contributed to Proliferation Inhibition, ...
- PubMed ID: 10.1080/21691401.2019.1709863, Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating...
- PubMed ID: 10.1080/10286020802410664, Apoptosis induced by baicalin involving up-regulation of P53 and bax in MCF-7 ce...
- PubMed ID: 10.1080/01902140490476337, SAFROLE OXIDE INDUCES APOPTOSIS IN A549 HUMAN LUNG CANCER CELLS
- PubMed ID: 10.1042/CBI20110102, The oncogenic role of NS5A of hepatitis C virus is mediated by up‐regulation o...
- PubMed ID: 10.1038/srep26722, A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cel...
- PubMed ID: 10.1021/acs.biomac.7b01197, Combined Phycocyanin and Hematoporphyrin Monomethyl Ether for Breast Cancer Trea...
- PubMed ID: 10.1016/j.molonc.2013.08.007, c-Ski activates cancer-associated fibroblasts to regulate breast cancer cell inv...
- PubMed ID: 10.1016/j.ijbiomac.2017.07.165, An innovative immunosensor for detection of tumor suppressor protein p53 in unpr...
- PubMed ID: 10.1016/j.humpath.2014.07.026, PBK/TOPK expression correlates with mutant p53 and affects patients prognosis an...
- PubMed ID: 10.1016/j.biopha.2017.04.044, Cisatracurium-induced proliferation impairment and death of colorectal cancer ce...
- PubMed ID: 10.1016/j.bbrc.2007.08.180, ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway
- PubMed ID: 10.1007/s11596-011-0141-9, Silencing MTA1 by RNAi reverses adhesion, migration and invasiveness of cervical...
- PubMed ID: 10.1002/ptr.5241, Isoflavones Extracted from Chickpea Cicer arietinum L. Sprouts Induce Mitochondr...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page