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- Table of Contents
Facts about TNFAIP3-interacting protein 2.
Involved in activation of this MEK/ERK signaling pathway during innate immune response; this purpose appears to be stimulus- and cell type specific. Required for stability of MAP3K8.
Human | |
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Gene Name: | TNIP2 |
Uniprot: | Q8NFZ5 |
Entrez: | 79155 |
Belongs to: |
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No superfamily |
A20-binding inhibitor of NF-kappa-B activation 2; A20-binding inhibitor of NF-kappaB activation-2; ABIN-2; ABIN2KLIP; Fetal liver LKB1-interacting protein; FLIP1DKFZp434J1313; MGC4289; TNFAIP3 interacting protein 2; TNFAIP3-interacting protein 2
Mass (kDA):
48.7 kDA
Human | |
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Location: | 4p16.3 |
Sequence: | 4; NC_000004.12 (2741648..2756336, complement) |
Ubiquitously expressed in all tissues examined.
Cytoplasm. Nucleus.
PMID: 11390377 by Van Huffel S.C., et al. Identification of a novel A20-binding inhibitor of nuclear factor- kappaB activation termed ABIN-2.
PMID: 12595760 by Liu W.-K., et al. An LKB1-interacting protein negatively regulates TNFalpha-induced NF- kappaB activation.