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- Table of Contents
8 Citations 9 Q&As
5 Citations 5 Q&As
Facts about Tumor necrosis factor ligand superfamily member 10.
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and Maybe also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
Induces apoptosis.Its activity could be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG which can't induce apoptosis. .
Human | |
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Gene Name: | TNFSF10 |
Uniprot: | P50591 |
Entrez: | 8743 |
Belongs to: |
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tumor necrosis factor family |
Apo-2 ligand; APO2L; Apo-2Ltumor necrosis factor (ligand) family, member 10; APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta; CD253 antigen; CD253; Protein TRAIL; TL2; TNF-related apoptosis-inducing ligand; TNFSF10; TRAIL; TRAILTNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor ligand superfamily member 10
Mass (kDA):
32.509 kDA
Human | |
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Location: | 3q26.31 |
Sequence: | 3; NC_000003.12 (172505508..172523430, complement) |
Widespread; most predominant in spleen, lung and prostate.
Cell membrane; Single-pass type II membrane protein. Secreted. Exists both as membrane-bound and soluble form.
PMID: 8777713 by Wiley S.R., et al. Identification and characterization of a new member of the TNF family that induces apoptosis.
PMID: 8663110 by Pitti R.M., et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
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