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- Table of Contents
2 Citations
2 Citations 1 Q&As
2 Citations
2 Citations 6 Q&As
Facts about Tumor necrosis factor receptor superfamily member 1B.
This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 cubes TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Human | |
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Gene Name: | TNFRSF1B |
Uniprot: | P20333 |
Entrez: | 7133 |
Belongs to: |
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No superfamily |
CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR; soluble TNFR1B variant 1; TNF RII; TNFBRp80 TNF-alpha receptor; TNF-R2; TNFR2TNFR1B; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II
Mass (kDA):
48.291 kDA
Human | |
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Location: | 1p36.22 |
Sequence: | 1; NC_000001.11 (12166948..12209222) |
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Tumor necrosis factor-binding protein 2]: Secreted.
PMID: 2172983 by Kohno T., et al. A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.
PMID: 2160731 by Smith C.A., et al. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.
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