TNFAIP6 Antibodies

Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. .

Gene Information

Human
Gene Name:	TNFAIP6
Uniprot:	P98066
Entrez:	7130

Family

Belongs to:
No superfamily

Alternative Names

Hyaluronate-binding protein; TNF alpha-induced protein 6; TNFAIP6; TNF-stimulated gene 6 protein; TSG6; TSG-6; TSG-6tumor necrosis factor alpha-inducible protein 6; TSG6tumor necrosis factor-inducible gene 6 protein; Tumor necrosis factor alpha-induced protein 6; tumor necrosis factor, alpha-induced protein 6; tumor necrosis factor-stimulated gene-6 protein

Molecular Weight

Mass (kDA):
31.203 kDA

Genomic Context

Human
Location:	2q23.3
Sequence:	2; NC_000002.12 (151357592..151380046)

Tissue Specificity

Found in the synovial fluid of patients with rheumatoid arthritis.

Diseases

• Inflammation
• Headache
• Arthritis
• Rheumatoid Arthritis
• Tissue Adhesions
• Malignant Neoplasms
• Neoplasms
• Autoimmune Reaction
• Tumor Angiogenesis
• Inflammatory Response
• Asthma
• Cell Invasion

• Degenerative Polyarthritis
• Cholangiocarcinoma
• Infertility
• Arthropathy
• Corneal Diseases
• Carcinoma
• Autoimmune Diseases

Interacting Proteins

• BMP2
• CCL19
• CCL2
• CCL7
• CXCL11

• CXCL8
• FN1
• GDF5
• PTX3
• TNFSF11

Pathways

• Ovulation
• Oocyte Maturation
• Pathogenesis
• Immune Response
• Cell Migration
• Inflammatory Response
• Localization
• Angiogenesis
• Secretion
• Cell Adhesion
• Fertilization
• Metaphase
• Reverse Transcription

• Tissue Remodeling
• Leukocyte Migration
• Estrus
• Meiosis
• Luteinization
• Bone Resorption
• Ossification

PTMs

• Phosphorylation
• Cleavage
• Biotinylation

• Glycosylation
• Oxidation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFAIP6

Best Uses Of The TNFAIP6 Marker

You may have wondered how to make the most of the TNFAIP6 protein in research if you are looking into it. There are many methods to accomplish this. To analyze your results, you can use Autoradiography or Enhanced Chemiluminescence detection, Colorimetric detection or Protein transfer efficiency. Continue reading to learn more. You'll thank yourself.

Autoradiography

Autoradiography allows scientists to determine the tissue localization for radioactive substances bound to specific enzymes, receptors or nucleic acids. Autoradiography can be used for many purposes, including biomedical research and environmental studies. However, there are some differences between autoradiography and MR spectroscopy. Here's a closer look to see how each differs.

The main differences between autoradiography and CT angiography are related to the distribution of overlying tissue. Major veins in leaflet tissues, for instance, are abaxially located and have thickened portions. The tissue thickness of the major veins and the leaflet skin is thicker than the leaflet's lamina. Therefore, the measured tracer activity is significantly underestimated in the major vessels. This is not a problem with CT angiography. It is compatible with plant PET scanners.

Enhanced Chemiluminescence detection

Enhanced chemiluminescence, a popular technique, is used to detect specific proteins found in biological samples. Its large dynamic range and excellent signal-to noise ratio make it useful in the quantification and detection biological materials. To make enhanced chemiluminescence, prepare total cell extracts in 1x RIPA buffer containing 150mmol/L Tris (0.25% sodium deoxycholate), and 1.0% IgepalCA-630. To use the ECL-Plus detection method, please follow the manufacturer's instructions.

CEBPD stimulates CCL20-IL23A and TNFAIP6 genes. Then, u937 cells were transiently transfected with the luciferase reporter gene. Materials and Methods describes the measurement of Luciferase activity. The data presented are the means and standard deviations of three independent experiments.

TNFAIP6 also represents a novel marker for NFKB pathway genes. This gene was previously associated in resistance. This study identified 141 clones and analysed their expression in resistant mice. We confirmed the presence of LIF and C8orf4 in resistant mice, which are associated with the TNFAIP6 marker.

Colorimetric detection

The results of this study show that 141 out of 141 clones passed TNFAIP6 expression's P-value filter. The MGMT clone however, was subject to a higher filter of.05. These results suggest that resistance could be caused by the MGMT genes. This marker should be identified and studied further. This study is the only to demonstrate the potential use of colorimetric TNFAIP6 analysis.

The TNFAIP3 gene is a new regulatory component of the cytoplasmic signaling pathway. Its expression is inversely correlated to the level zinc finger protein A20. In a recent study, the expression of TNFAIP3 was associated with NF-kB activation in resistant glioblastomas. The study results showed that a prediction model using resistance signatures subclassified 31 glioblastomas in two groups based upon TNFAIP3. TNFAIP3 was also part of an optimized 4-gene predictive factor for significant patient mortality.

Many tissues of the body have been found to harbor the TNFAIP6 genetic. A combination of a protein-binding induced signaling approach and a novel DNAzyme DNAzyme conformational switching strategy has created a sensitive colorimetric analyzer. The most effective way to detect this marker is with a colorimetric assay that only contains one antibody.