This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Transmembrane and immunoglobulin domain-containing protein 2.
Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. .
Human | |
---|---|
Gene Name: | TMIGD2 |
Uniprot: | Q96BF3 |
Entrez: | 126259 |
Belongs to: |
---|
No superfamily |
CD28H; IGPR1; IGPR-1; MGC23244; TMIGD2; transmembrane and immunoglobulin domain containing 2; transmembrane and immunoglobulin domain-containing protein 2
Mass (kDA):
30.675 kDA
Human | |
---|---|
Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (4292227..4302439, complement) |
Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double- negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level).
Cell membrane; Single-pass type I membrane protein.
PMID: 22419821 by Rahimi N., et al. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis.
PMID: 23784006 by Zhu Y., et al. B7-H5 costimulates human T cells via CD28H.