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- Table of Contents
Facts about Post-GPI attachment to proteins factor 6.
Has phospholipase A2 action that removes an acyl-chain in the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface.
Mouse | |
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Gene Name: | Tmem8a |
Uniprot: | Q9ESN3 |
Entrez: |
Belongs to: |
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TMEM8 family |
five-span transmembrane protein M83; Protein M83; TMEM6; TMEM8; Transmembrane protein 6M83; transmembrane protein 8 (five membrane-spanning domains); Transmembrane protein 8; transmembrane protein 8A
Mass (kDA):
85.329 kDA
Mouse | |
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Location: | |
Sequence: | ; |
PMID: 11006113 by Motohashi T., et al. Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83.
PMID: 27881714 by Lee G.H., et al. A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.