Transmembrane protein 65 (Tmem65)

May play a significant role in cardiac development and function. May regulate cardiac conduction as well as the purpose of the gap junction protein GJA1.

May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (PubMed:26403541). Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity).