Transmembrane protein 119 Antibodies

AND Tmem119 ELISA kits, Transmembrane protein 119 Proteins

Many biological assays use antibodies to detect Transmembrane protein 119, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transmembrane protein 119 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transmembrane protein 119 antibodies...

We validate the specificity of these antibodies to Transmembrane protein 119 by testing them on tissues known to express Tmem119 positively and negatively. Browse below to find the Tmem119 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Tmem119 Infographic by Boster Bio

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TMEM119 (NM_181724) Human Over-expression Lysate

Human

$628
Cat # LS338773
100 µg

Tmem119 Overview

Facts about Transmembrane protein 119.

Transmembrane protein 119 (Tmem119)

Plays an essential role in bone formation and normal bone mineralization (PubMed:26207632, PubMed:22416756, PubMed:20025746). Promotes the differentiation of myoblasts to osteoblasts (PubMed:22416756, PubMed:20025746, PubMed:22579779).

May induce the commitment and differentiation of myoblasts to osteoblasts through an enhancement of BMP2 creation and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Upregulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451).

Gene Information

Mouse
Gene Name:	Tmem119
Uniprot:	Q8R138
Entrez:	231633

Family

Belongs to:

No superfamily

Alternative Names

OBIF; Osteoblast Induction Factor; TMEM119

Molecular Weight

Mass (kDA):
29.401 kDA

Genomic Context


Mouse

Location:	5\|5 F
Sequence:	5;

Tissue Specificity

Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis (PubMed:26207632). Predominantly expressed in osteoblasts (PubMed:20025746).

Diseases

Hypoplasia
Fibrodysplasia Ossificans Progressiva
Heterotopic Ossification

Pathways

Osteoblast Differentiation
Regeneration
Ossification
Pathogenesis
Bmp Signaling Pathway

PTMs

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tmem119

References

PMID: 20025746 by Kanamoto T., et al. Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation.

PMID: 21239498 by Hisa I., et al. Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.