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- Table of Contents
Facts about Transmembrane 7 superfamily member 3.
Is a downstream transcriptional target of p53/TP53, and functions as a pro- survival homeostatic factor that attenuates the growth of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
Human | |
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Gene Name: | TM7SF3 |
Uniprot: | Q9NS93 |
Entrez: | 51768 |
Belongs to: |
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No superfamily |
Transmembrane 7 superfamily member 3
Mass (kDA):
64.166 kDA
Human | |
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Location: | 12p11.23 |
Sequence: | 12; NC_000012.12 (26966524..27014427, complement) |
Cell membrane; Multi-pass membrane protein.
PMID: 10828615 by Akashi H., et al. Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3.
PMID: 21853325 by Beck A., et al. An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.