Toll-like receptor 10 Antibodies

Toll-like receptor 10 (TLR10)

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

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Gene Information

Human
Gene Name:	TLR10
Uniprot:	Q9BXR5
Entrez:	81793

Family

Belongs to:
Toll-like receptor family

Alternative Names

CD290 antigen; CD290; MGC104967; MGC126398; MGC126399; TLR10; toll-like receptor 10

Molecular Weight

Mass (kDA):
94.564 kDA

Genomic Context

Human
Location:	4p14
Sequence:	4; NC_000004.12 (38772238..38782990, complement)

Tissue Specificity

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Innate Immune Response
• Inflammation
• Malignant Neoplasms
• Asthma
• Neoplasms
• Inflammatory Response
• Infective Disorder
• Carcinoma
• Chronic Inflammation
• Dysequilibrium Syndrome
• Malignant Paraganglionic Neoplasm
• Immediate Hypersensitivity
• Tissue Adhesions

• Corneal Diseases
• Bacterial Infections
• Virus Diseases
• Leukemia
• Burkitt Lymphoma
• Lymphoma
• Allergic Asthma

Interacting Proteins

• TLR1
• TLR2

Pathways

• Immune Response
• Pathogenesis
• Innate Immune Response
• Secretion
• Inflammatory Response
• Localization
• Cytokine Production
• Cell Activation
• Reverse Transcription
• Disease Resistance
• Cytokine Secretion
• Adaptive Immune Response
• Toll-like Receptor Signaling Pathway

• Viral Replication
• Transport
• Activation Of Innate Immune Response
• Interleukin-6 Secretion
• Mast Cell Activation
• Gene Conversion
• Sensitization

PTMs

• Phosphorylation

• Glycosylation

Research Areas

• Cytokine Research
• Immunology
• Innate Immunity

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLR10

Best Uses of the TLR10 Marker by Boster Bio

This article contains valuable information, whether you are a scientist/consumer or a researcher. This article will explain how the marker was validated and optimized. This article can help you determine if you require a specific panel of antibodies. Boster Bio leads the way in TLR10 antibody technology. Boster Bio's products can help you find the right solution for your research.

Boster Bio

The TLR10 marker is an important protein-coding gene. It is associated to diseases such as Crimean Congo hemorhagic Fever and Melioidosis. It is a member of the TNF Superfamily. It has transmembrane signals receptor activity and is related with the NFKappaB Pathway. TLR10 has a paralog, TLR1, that is the same coding gene.

Anti-Tolllike receptor 10 TLR10Antibody

The Boster Bio Anti-Toll-like Receptor 10 Antibody (TLR10) was designed to detect TLR10 in cells. This antigen is an important component of the innate immunity system. It is encoded in the gene TLR10. The antigen can be found in the blood of many mammals, including monkeys or dogs. The antigen is also available from the rat.

The 300BCG cohort included 321 healthy individuals from Holland. The study did not include individuals who did not meet the inclusion criteria. The study included 139 men and 182 ladies, both of Western European origin. The blood was drawn before, two weeks after, three months after and three months after vaccination. These blood samples were used as a basis for the isolation and identification of PBMCs. In vitro study of the TLR10 SNP N241H.

TLRs, or toll-like receptors, play a crucial role in innate immune system. They detect damage-associated molecular pattern in damaged cells. The Toll/interleukin-1 receptor molecule is located inside cells and undergoes structural adjustments required for downstream signaling. These receptors play an important role in the recognition of foreign agents and inducing immune responses to these pathogens.

This antibody is designed to recognize TLR10 proteins, bind to them and inhibit their activity. This antibody detects TLR4 and TLR10 proteins in human. TLR10 is detected in TLR4 positive cells. This is useful for identifying TLR proteins in cancerous tissues. This antibody is a high grade anti-TLR10 antibodies for cell culture.

Phase I clinical trials for the human anti TLR4 monoclonal antibody are currently underway. NovImmune SA will fund this study. TLR4 ligation activates the nuclear factor-kB (NF-kB), which plays a pivotal role in inflammation and cell proliferation. Numerous drugs inhibit the activity of NF-kB, including non-steroidal anti-inflammatory medications (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), and corticosteroids.

Validation

TLR10 genes are expressed in many organs including the brain. The gene expression level can also be detected by real-time Polymerase Chain Reaction (PCR). The sequence is cloned into the respective pTAdV and pDisplay vectors. This method has been validated by performing a PCR analysis using a pool containing monocytes or NKT from TLR10 people.

The full-length TLR10 genetic sequence was cloned to pDisplay vector from Invitrogen. The TLR10 sequence was used to create a PCR primer and probe. The TLR10 construct had twelve hundred bp of DNA. It was digested in AccI and BglII. The TLR10 gene was used as an immunestaining agent.

TLR10 is a member the TNF superfamily. It is involved with the NF-kappaB pathway, and is closely related with the TNF superfamily. It is a transmembrane receptor with transmembrane signaling functions. Its paralog TLR1 could be a target for therapeutic interventions. Further research is needed into the gene's function.

TLR4 is also important in the cancer microenvironment. It is also associated to prognosis. Patients with low levels of TLR4 showed increased drug sensitivity following chemotherapy. This could be due a decrease at cg14629571 in TLR4 promoter methylation. Further research is required to discover the mechanisms by which TLR4 regulates immune cell function.

TLR4 expression is associated with gene expression changes and alterative pathways, in addition to its role as a tumor-growth regulator. Low and high-TLR4 expression groups were significantly enriched in E2F targets, TGF-b signaling, and the G2M checkpoint. Furthermore, TLR4 expression was associated with decreased expression of other genes involved in spermatogenesis, DNA replication, and mismatch repair.

Optimization

A new technology that targets pathogen-associated molecular structures using antibodies is based on TLRs. Many PRR-agonists are either in early clinical trials or late preclinical stages, including tiluzumab. It targets TLR10 on cell surfaces. Lipopolysaccharides are components of the outer membrane of Gram-negative bacteria. The TLRs recognize these patterns in the presence of lipids.

Boster Biologicals developed proprietary antibody- and ELISA kits for TLR10 markers. These kits can detect many biomarkers within neuroscience, developmental biology, or inflammation. Their products are based in proprietary trade secrets and can detect biomarkers as low as picograms. In addition, Boster Bio rewards early reviewers of its products with product credits, rewarding them for their efforts.

Applications

The TLR10 protein marker is a protein that has multiple leucine rich repeats. It is transmembrane-domain and cytoplasmic TOLL interleukin-1 (receptor) domain. TLR10 cells can be found in many tissues and organs. It is not known what the health effects of its variant sequence variants will be. These researchers are continuing to study the TLR10 gene to learn more about its applications.

TLR10 has been shown to be associated with autoimmune and inflammatory diseases. Studies have shown that genetic polymorphisms within the TLR10 gene can increase risk for Crohn’s disease, HIV infection and H. Pylori infections. In addition, studies have shown a link between polymorphisms in TLR10 and thyroid disease.

While the function and ligand of TLR10 are unknown, the gene is expressed in tissues rich in immune cells, such as the lung, lymph nodes, and spleen. TLR10 does not exist in naive human B cells. However it is induced quickly by activation of B-cell receptor. These results indicate that TLR10 could be an important marker in the diagnosis of disease. There is no clear consensus on whether TLR10 expression is associated with disease.

TLR10 is the human equivalent of Drosophila TOLL. It recognizes specific pathogen elements and acts as a protein. It is located on chromosome 4. In humans, the TLR10 gene carries 78 single nucleotide polymorphisms in the human genome. Toll-like receptors are crucial for activating adaptive immune reactions and releasing soluble substances and costimulatory chemicals.