TLE family member 5 Antibodies

AND TLE5 ELISA kits, TLE family member 5 Proteins

Many biological assays use antibodies to detect TLE family member 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TLE family member 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TLE family member 5 antibodies...

We validate the specificity of these antibodies to TLE family member 5 by testing them on tissues known to express TLE5 positively and negatively. Browse below to find the TLE5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TLE5 Infographic by Boster Bio

All TLE5 Products

Product

Figures

Specificity

Applications

Price

Amino terminal enhancer of split (AES) (NM_001130) Human Recombinant Protein

$1249
Cat # PROTQ08117
20 µg

Amino terminal enhancer of split (AES) (NM_001130) Human Over-expression Lysate

Human

$628
Cat # LS000166
100 µg

TLE5 Overview

Facts about TLE family member 5.

TLE5 3D structure. Source: alphafold

TLE family member 5 (TLE5)

Transcriptional corepressor. Acts as dominant repressor towards other family members.

Inhibits NF-kappa-B-regulated gene expression. May be necessary for the initiation and maintenance of the differentiated state.

Gene Information

Human
Gene Name:	TLE5
Uniprot:	Q08117
Entrez:	166

Family

Belongs to:

WD repeat Groucho/TLE family

Alternative Names

AES-1; AES-2; Amino enhancer of split; amino-terminal enhancer of split; ESP1; Gp130-associated protein GAM; GRG; GRG5; Protein ESP1; Protein GRG; TLE5

Molecular Weight

Mass (kDA):
21.97 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (3052910..3063107, complement)

Tissue Specificity

Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.

Subcellular Localizations

Nucleus.

Diseases

Radiation Injury
Indifferent Mood
Depressive Disorder
Neoplasms
Malignant Neoplasms
Carcinoma
Encephalitis
Japanese Encephalitis
Epilepsy
Infective Disorder
Major Depressive Disorder
Tissue Adhesions

Cardiovascular Diseases
Mental Disorders
Dementia
Alzheimer's Disease
Polycystic Ovary Syndrome
Parkinson Disease
Nervousness

Pathways

Localization
Transport
Pathogenesis
Excretion
Aging
Secretion
Virulence
Flight
Cell Death
Hypersensitivity
Translation
Cell Adhesion
Transposition

Cell Differentiation
Cognition
Segmentation
Somitogenesis
Hemopoiesis
Gastric Emptying
Neurogenesis

PTMs

Oxidation
Carboxylation
Phosphorylation

Glycosylation
Acetylation
Methylation

Acylation

Research Areas

Apoptosis
Signal Transduction
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLE5

References

PMID: 9809752 by Hou E.W., et al. Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N- terminal domain of Drosophila enhancer of split Groucho protein.

PMID: 8365415 by Miyasaka H., et al. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.