TKTL1 Antibodies

AND TKTL1 ELISA kits, TKTL1 Proteins

Many biological assays use antibodies to detect TKTL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TKTL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TKTL1 antibodies...

We validate the specificity of these antibodies to TKTL1 by testing them on tissues known to express TKTL1 positively and negatively. Browse below to find the TKTL1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TKTL1 Infographic by Boster Bio

All TKTL1 Products

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Product

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Specificity

Applications

Price

TKTL1 (NM_012253) Human Recombinant Protein

$1249
Cat # PROTP51854
20 µg

TKTL1 (NM_012253) Human Over-expression Lysate

Human

$628
Cat # LS008277
100 µg

Anti-TKR/TKTL1 Antibody Picoband®

Human, Mouse, Rat

$370
Cat # A05309-1
100 μg/vial

TKTL1 Overview

Facts about Transketolase-like protein 1.

TKTL1 3D structure. Source: alphafold

Transketolase-like protein 1 (TKTL1)

Catalyzes the transfer of a two-carbon ketol group from a ketose donor into an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. .

Gene Information

Human
Gene Name:	TKTL1
Uniprot:	P51854
Entrez:	8277

Family

Belongs to:

transketolase family

Alternative Names

TK 2; TKR EC 2.2.1.1; TKR; TKT2Transketolase 2; transketolase-2; transketolase-like 1; transketolase-like protein 1; Transketolase-related protein

Molecular Weight

Mass (kDA):
65.333 kDA

Genomic Context


Human

Location:	Xq28
Sequence:	X; NC_000023.11 (154295795..154330350)

Tissue Specificity

Expressed in fetal and adult heart, brain, lung, liver, and kidney, and in adult placenta, skeletal muscle and pancreas. Up-regulated in various epithelial tumors.

Subcellular Localizations

Cytoplasm. Nucleus. Predominantly cytoplasmic and to a lesser extent also nuclear (PubMed:16969476).

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Malignant Squamous Cell Neoplasm
Malignant Neoplasm Of Lung
Cell Transformation, Neoplastic
Lymphatic Metastasis
Adenocarcinoma
Tumor Progression
Malignant Neoplasm Of Breast

Non-small Cell Lung Carcinoma
Carcinogenesis
Lung Neoplasms
Cell Invasion
Malignant Tumor Of Colon
Colonic Neoplasms

Pathways

Glycolysis
Fermentation
Cell Proliferation
Angiogenesis
Pathogenesis
Gene Silencing
Demethylation
Regeneration
Cell Cycle

Cell Death
Cell Growth
Invasive Growth
Oncogenesis

PTMs

Demethylation
Nitrosylation
Phosphorylation

Reduction
Cleavage
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TKTL1

References

PMID: 8838793 by Coy J.F., et al. Molecular cloning of tissue-specific transcripts of a transketolase- related gene: implications for the evolution of new vertebrate genes.

PMID: 15991799 by Coy J.F., et al. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer.