TJP2 Antibodies

Tight junction protein ZO-2 (TJP2)

Plays a part in tight junctions and adherens junctions. .

Gene Information

Human
Gene Name:	TJP2
Uniprot:	Q9UDY2
Entrez:	9414

Family

Belongs to:
MAGUK family

Alternative Names

C9DUPq21.11; DFNA51; DUP9q21.11; MGC26306; tight junction protein 2 (zona occludens 2); Tight junction protein 2; TJP2; X104; X104tight junction protein ZO-2; ZO2; ZO-2; ZO2Friedreich ataxia region gene X104 (tight junction protein ZO-2); Zona occludens protein 2; Zonula occludens protein 2

Molecular Weight

Mass (kDA):
133.958 kDA

Genomic Context

Human
Location:	9q21.11
Sequence:	9; NC_000009.12 (69121006..69255208)

Tissue Specificity

This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.

Subcellular Localizations

Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus. Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.

Diseases

• Neoplasms
• Tissue Adhesions
• Malignant Neoplasms
• Inflammation
• Carcinoma
• Nervousness
• Edema
• Adenocarcinoma
• Cardiovascular Diseases
• Inflammatory Bowel Diseases
• Brain Edema
• Pancreatic Neoplasm
• Hiv Infections

• Dementia
• Immunologic Deficiency Syndromes
• Presbycusis
• Pathologic Neovascularization
• Pancreatic Adenocarcinoma
• Malignant Paraganglionic Neoplasm
• Aids Dementia Complex

Interacting Proteins

• LASP1

Pathways

• Localization
• Pathogenesis
• Cell Proliferation
• Transport
• Methylation
• Blastocyst Formation
• Cell-cell Adhesion
• Mitosis
• Cell Differentiation
• Establishment Of Cell Polarity
• Inflammatory Response
• Cell Cycle
• Ion Transport

• Secretion
• Cell Activation
• Cell Migration
• Skin Development
• Tight Junction Assembly
• Nuclear Export
• Spermatogenesis

PTMs

• Phosphorylation
• Dephosphorylation

• Methylation
• Demethylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TJP2

Best Uses Of The TJP2 Marker For Cancer Research

Many biological assays employ antibodies against Tight Junction protein ZO-2 (TJP2) These antibodies can be monoclonal, polyclonal, and react with TJP2 from animal samples. Boster Bio's TJP2 antibodies are developed using TJP2 antibodies from rabbit and mouse. This protein is found in the junctions of epithelial cell membranes.

Anti-Tight Junction Protein ZO-2 TJP2

Boster Bio Anti-Tight Junction Protein, (TJP2) marker is an effective tool for the detection of TJP2, Zona Occludens2, in samples such as whole blood and cell culture supernatants. The antibody is able to react with Human and is made up of 5mg BSA (and peptides). You can purchase a blocking protein to stop the antibody from binding your immunogen.

qRTPCR was used for determining the expression levels of TJP1 (and TJP2) in human intestines. The mRNA levels of these proteins were normalized to b-actin mRNA levels. The formula 2 + DCt of gene + DCtof b-actin was used for computing the fold change in relative expression. Each sample was taken in triplicate. Standard deviations can be indicated by error bars.

Immunoblotting

These studies show that the TJP2 marker is most effective in cancer research. These studies were conducted on human lung carcinoma tissues. The results were published by the Journal of Clinical Investigation. These findings will be discussed below. In addition to identifying the TJP2 gene, this marker can also be useful for analyzing other cancer markers, such as the PDGF receptor.

Immunofluorescence

The TJP2 marker is a common protein that is found in epithelial cells at junctions. This protein is detected in many biological assays using antibodies. These antibodies can react in many animal samples with TJP2 and can be monoclonal or multiclonal. Boster Bio produces TJP2 antibodies using rabbit tissues and mouse tissues. It is the most widely used marker in immunohistochemistry and Western Blotting.

ICC

The TJP2 indicator is a widely used biomarker (ICC) in immunocytochemistry. It has many applications, including identifying cell cells, detecting cellular damages, and determining if there are any cancer cells. It is also known by the Zona occludens. The TJP2 gene is located in the Friedreich ataxia critical region, approximately 70 kb centromeric from the X123 gene. It is transcribed in a centromere-to-telomere direction. TJP1 is thought to interact with TJP2 via claudin-1, claudin-2.