Acyl-CoA 6-desaturase Antibodies

AND FADS2 ELISA kits, Acyl-CoA 6-desaturase Proteins

Many biological assays use antibodies to detect Acyl-CoA 6-desaturase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Acyl-CoA 6-desaturase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Acyl-CoA 6-desaturase antibodies...

We validate the specificity of these antibodies to Acyl-CoA 6-desaturase by testing them on tissues known to express FADS2 positively and negatively. Browse below to find the FADS2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FADS2 Infographic by Boster Bio

All FADS2 Products

Product

Figures

Specificity

Applications

Price

Anti-Fatty acid desaturase 2 FADS2 Antibody

Human, Mouse, Rat

$405
Cat # A01220
100ul

FADS2 (NM_004265) Human Recombinant Protein

$1249
Cat # PROTO95864
20 µg

Anti-FADS2 Antibody (Center)

Human

Flow Cytometry, IHC-P, WB

$298
Cat # A01220-1
80 µl

FADS2 (NM_004265) Human Over-expression Lysate

Human

$960
Cat # LS009415
100 µg

FADS2 Overview

Facts about Acyl-CoA 6-desaturase.

FADS2 3D structure. Source: alphafold

Acyl-CoA 6-desaturase (FADS2)

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) lipoic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) to gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps.

Highly unsaturated fatty acids (HUFA) play critical roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.

Gene Information

Human
Gene Name:	FADS2
Uniprot:	O95864
Entrez:	9415

Family

Belongs to:

fatty acid desaturase type 1 family

Alternative Names

D6DLLCDL2; Delta(6) desaturase; Delta(6) fatty acid desaturase; Delta-6 desaturase; delta-6 fatty acid desaturase; delta-6-desaturase; DES6; EC 1.14.19; EC 1.14.19.-; FADSD6; fatty acid desaturase 2; linoleoyl-CoA desaturase (delta-6-desaturase)-like 2; SLL0262; TU13

Molecular Weight

Mass (kDA):
52.259 kDA

Genomic Context


Human

Location:	11q12.2
Sequence:	11; NC_000011.10 (61816203..61867354)

Tissue Specificity

Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Inflammation
Cardiovascular Diseases
Dysequilibrium Syndrome
Insulin Resistance
Obesity
Malignant Neoplasms
Diabetes Mellitus
Eczema
Dyslipidemias
Heart Diseases
Coronary Artery Disease
Dermatitis, Atopic
Arthritis

Rhinorrhea
Insulin Sensitivity
Allergic Rhinitis (disorder)
Fibrosis
Diabetes Mellitus, Non-insulin-dependent
Depressive Disorder
Nervousness

Pathways

Lactation
Methylation
Transport
Localization
Pathogenesis
Brain Development
Gluconeogenesis
Lipid Homeostasis
Cognition
Secretion
Gene Silencing
Fatty Acid Elongation
Aging

Immune Response
Regulation Of Gene Expression
Myelination
Embryo Development
Inflammatory Response
Sensitization
Translation

PTMs

Methylation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FADS2

References

PMID: 9867867 by Cho H.P., et al. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.

PMID: 10860662 by Marquardt A., et al. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.