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TIPIN Antibodies
AND TIPIN ELISA kits, TIPIN Proteins
Many biological assays use antibodies to detect TIPIN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TIPIN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TIPIN antibodies...
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TIPIN Overview
Facts about TIMELESS-interacting protein.
TIMELESS-interacting protein (TIPIN)
Plays an important part in the control of DNA replication as well as the maintenance of replication fork stability. Important for cell survival following DNA damage or replication stress.
May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication procedures under both normal and stress conditions, stabilizes replication forks and affects both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
Gene Information
| Human | |
|---|---|
| Gene Name: | TIPIN |
| Uniprot: | Q9BVW5 |
| Entrez: | 54962 |
Family
| Belongs to: |
|---|
| CSM3 family |
Alternative Names
FLJ20516; TIMELESS interacting protein; TIMELESS-interacting protein
Molecular Weight
Mass (kDA):
34.555 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q22.31 |
| Sequence: | 15; NC_000015.10 (66334974..66387273, complement) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Genomic Instability
- Genotoxic Stress
- Carcinogenesis
- Neoplasms
- Cell Transformation, Neoplastic
- Ataxia Telangiectasia
- Ataxia
- Colorectal Cancer
- Retinoblastoma
- Colorectal Neoplasms
- Telangiectasis
Interacting Proteins
- RPA2
- TEX11
Pathways
- Dna Replication
- Cell Cycle
- S Phase
- Replication Fork Protection
- Sister Chromatid Cohesion
- Dna Damage Checkpoint
- Mitosis
- Dna Repair
- Cell Cycle Checkpoint
- Circadian Rhythm
- Establishment Of Sister Chromatid Cohesion
- Localization
- Dna Replication Checkpoint
PTMs
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIPIN
bosterbio.com/bosterbio-gene-info-cards/TIPIN
References
PMID: 12875843 by Gotter A.L.; Tipin, a novel timeless-interacting protein, is developmentally co- expressed with timeless and disrupts its self-association.
PMID: 17116885 by Chou D.M., et al. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.