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THO complex subunit 1 Antibodies
AND THOC1 ELISA kits, THO complex subunit 1 Proteins
Many biological assays use antibodies to detect THO complex subunit 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with THO complex subunit 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop THO complex subunit 1 antibodies...
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THOC1 Infographic by Boster Bio
All THOC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M04626
100 μl
Cat # M04626
100 μl
Human
$628
Cat # LS009984
100 µg
Cat # LS009984
100 µg
THOC1 Overview
Facts about THO complex subunit 1.
THO complex subunit 1 (THOC1)
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex that's believed to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA.
TREX is recruited to spliced mRNAs with a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and can be recruited in a splicing- and cap-dependent way to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm through the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Gene Information
| Human | |
|---|---|
| Gene Name: | THOC1 |
| Uniprot: | Q96FV9 |
| Entrez: | 9984 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
HPR1THO complex subunit 1; hTREX84; Nuclear matrix protein p84; P84; P84N5; THO complex 1; tho1
Molecular Weight
Mass (kDA):
75.666 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18p11.32 |
| Sequence: | 18; NC_000018.10 (214348..268047, complement) |
Tissue Specificity
Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression.
Subcellular Localizations
[Isoform 1]: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.; [Isoform 2]: Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Neoplasm Metastasis
- Carcinoma
- Mammary Neoplasms
- Genomic Instability
- Malignant Neoplasm Of Breast
- Pancreatic Neoplasm
- Adenocarcinoma
- Fibromyalgia
Interacting Proteins
- MOAP1
- RABGEF1
- THOC5
- TRIM54
- USHBP1
Pathways
- Cell Death
- Rna Processing
- Cell Proliferation
- Nuclear Export
- Cell Cycle
- Cell Growth
- Induction Of Apoptosis
- Transport
- Cell Cycle Checkpoint
- Mrna Transport
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/THOC1
bosterbio.com/bosterbio-gene-info-cards/THOC1
References
PMID: 7525595 by Durfee T., et al. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing.
PMID: 15358532 by Gasparri F., et al. The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.