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Transcription factor Dp-1 Antibodies
AND TFDP1 ELISA kits, Transcription factor Dp-1 Proteins
Many biological assays use antibodies to detect Transcription factor Dp-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor Dp-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor Dp-1 antibodies...
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TFDP1 Infographic by Boster Bio
All TFDP1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1175
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1175
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M04204
100 μl/vial
Cat # M04204
100 μl/vial
TFDP1 Overview
Facts about Transcription factor Dp-1.
Transcription factor Dp-1 (TFDP1)
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537).
The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Gene Information
| Human | |
|---|---|
| Gene Name: | TFDP1 |
| Uniprot: | Q14186 |
| Entrez: | 7027 |
Family
| Belongs to: |
|---|
| E2F/DP family |
Alternative Names
DP1E2F dimerization partner 1; DRTF1Dp-1; DRTF1-polypeptide 1; E2F-related transcription factor; transcription factor Dp-1
Molecular Weight
Mass (kDA):
45.07 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q34 |
| Sequence: | 13; NC_000013.11 (113584688..113641473) |
Tissue Specificity
Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
Subcellular Localizations
Nucleus. Cytoplasm. Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1.
Diseases
- Retinoblastoma
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Hyperplasia
- Growth Arrest
- Cell Transformation, Neoplastic
- Osteosarcoma
- Embryonal Carcinoma
- Lymphoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Liver Carcinoma
Interacting Proteins
- DVL1
- E2F1
- E2F4
- E2F6
- MAX
- NLK
Pathways
- Cell Cycle
- S Phase
- Cell Proliferation
- Cell Growth
- Cell Cycle Arrest
- G1 Phase
- Cell Death
- Localization
- Cell Division
- Dna Replication
- Hyperphosphorylation
- Oncogenesis
- Induction Of Apoptosis
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TFDP1
bosterbio.com/bosterbio-gene-info-cards/TFDP1
References
PMID: 8405995 by Helin K., et al. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.
PMID: 8039504 by Bandara L.R., et al. DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.