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TERF2IP Antibodies
AND TERF2IP ELISA kits, TERF2IP Proteins
Many biological assays use antibodies to detect TERF2IP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TERF2IP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TERF2IP antibodies...
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TERF2IP Overview
Facts about Telomeric repeat-binding factor 2-interacting protein 1.
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP)
Involved in the regulation of telomere length and protection as a part of the shelterin complex (telosome). In contrast to other elements of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair.
Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which may affect telomere length. Doesn't bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats through its interaction with TERF2.
Gene Information
| Human | |
|---|---|
| Gene Name: | TERF2IP |
| Uniprot: | Q9NYB0 |
| Entrez: | 54386 |
Family
| Belongs to: |
|---|
| RAP1 family |
Alternative Names
dopamine receptor interacting protein 5; Dopamine receptor-interacting protein 5; DRIP5; hRap1; RAP1 homolog; RAP1TERF2-interacting telomeric protein 1; Repressor/activator protein 1 homolog; telomeric repeat binding factor 2, interacting protein; telomeric repeat-binding factor 2-interacting protein 1; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric RAP1 protein
Molecular Weight
Mass (kDA):
44.26 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q23.1 |
| Sequence: | 16; NC_000016.10 (75647737..75657442) |
Tissue Specificity
Ubiquitous. Highly expressed.
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. Chromosome, telomere. Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Carcinoma
- Malignant Neoplasm Of Pancreas
- Cell Invasion
- Malignant Neoplasm Of Breast
- Pathologic Neovascularization
- Dysequilibrium Syndrome
- Adenocarcinoma
- Prostatic Neoplasms
- Cardiovascular Diseases
- Malignant Neoplasm Of Prostate
Pathways
- Cell Proliferation
- Cell Adhesion
- Cell Migration
- Chemotaxis
- Cell Motility
- Cell Cycle
- Prophase
- Telomere Maintenance
- Plasmid Maintenance
- Exocytosis
- Localization
- Dna Replication
- Cell Death
PTMs
- Phosphorylation
- Methylation
Research Areas
- Cellular Markers
- Chromatin Research
- DNA Repair
- Endosome Markers
- Lysosome Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TERF2IP
bosterbio.com/bosterbio-gene-info-cards/TERF2IP
References
PMID: 10850490 by Li B., et al. Identification of human RAP1: implications for telomere evolution.
PMID: 14659874 by Tan M., et al. The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes.