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- Table of Contents
Facts about Transcription factor E2-alpha.
Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or premature B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'.
Human | |
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Gene Name: | TCF3 |
Uniprot: | P15923 |
Entrez: | 6929 |
Belongs to: |
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No superfamily |
bHLHb21; bHLHb21TCF-3; Class B basic helix-loop-helix protein 21; E2A immunoglobulin enhancer-binding factor E12/E47; E2A; E2AKappa-E2-binding factor; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; ITF1; ITF1Transcription factor ITF-1; Kappa-E2-binding factor; MGC129647; MGC129648; Pan2; TCF-3; Tcfe2a; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcription factor 3; transcription factor E2-alpha; VDIR; VDR interacting repressor
Mass (kDA):
67.6 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (1609292..1652615, complement) |
Nucleus.
PMID: 1967983 by Kamps M.P., et al. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.
PMID: 1967982 by Nourse J., et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.