TCF3 Antibodies

AND TCF3 ELISA kits, TCF3 Proteins

Many biological assays use antibodies to detect TCF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TCF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TCF3 antibodies...

We validate the specificity of these antibodies to TCF3 by testing them on tissues known to express TCF3 positively and negatively. Browse below to find the TCF3 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TCF3 Infographic by Boster Bio

All TCF3 Products

Product

Figures

Specificity

Applications

Price

Anti-TCF3/E2A Antibody

7 Q&As

Human, Mouse, Rat

IHC, WB

$360
Cat # A00095
100 µl

Anti-Phospho-E2A (T355) TCF3 Antibody

Human, Mouse, Rat

ELISA, IHC

$380
Cat # A00095T355
100ul

TCF3 / E2A (TCF3) (NM_003200) Human Recombinant Protein

$1249
Cat # PROTP15923
20 µg

TCF3 / E2A (TCF3) (NM_003200) Human Over-expression Lysate

Human

$960
Cat # LS006929
100 µg

TCF3 Overview

Facts about Transcription factor E2-alpha.

TCF3 3D structure. Source: alphafold

Transcription factor E2-alpha (TCF3)

Transcriptional regulator. Involved from the initiation of neuronal differentiation.

Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or premature B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'.

Gene Information

Human
Gene Name:	TCF3
Uniprot:	P15923
Entrez:	6929

Family

Belongs to:

No superfamily

Alternative Names

bHLHb21; bHLHb21TCF-3; Class B basic helix-loop-helix protein 21; E2A immunoglobulin enhancer-binding factor E12/E47; E2A; E2AKappa-E2-binding factor; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; ITF1; ITF1Transcription factor ITF-1; Kappa-E2-binding factor; MGC129647; MGC129648; Pan2; TCF-3; Tcfe2a; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcription factor 3; transcription factor E2-alpha; VDIR; VDR interacting repressor

Molecular Weight

Mass (kDA):
67.6 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (1609292..1652615, complement)

Subcellular Localizations

Nucleus.

Diseases

Leukemia
Neoplasms
Malignant Neoplasms
Acute Lymphocytic Leukemia
Lymphoma
Carcinoma
Chromosomal Translocation
Leukemogenesis
Cell Transformation, Neoplastic
Nervousness
Precursor B-cell Lymphoblastic Leukemia-lymphoma
Lymphohistiocytosis, Hemophagocytic
Burkitt Lymphoma

Neoplasm Metastasis
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Tissue Adhesions
Malignant Paraganglionic Neoplasm
Cell Invasion
T-cell Lymphoma
Crest Syndrome

Interacting Proteins

ASCL1
CCNDBP1
FOXH1
ID2
ID3

MYOD1
PSMD9
TAL1
TCAF1

Pathways

Cell Development
Cell Differentiation
Cell Cycle
Cell Proliferation
Pathogenesis
V(d)j Recombination
Methylation
Localization
Dna Methylation
Gastrulation
Senescence
B Cell Differentiation
Neurogenesis

Axis Specification
Rna Interference
Brain Development
Cell Growth
Aging
Cell-cell Adhesion
T Cell Differentiation

PTMs

Phosphorylation
Methylation
Acetylation
Ubiquitination

Demethylation
Deacetylation
Cleavage
Reduction

Glycosylation

Research Areas

Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCF3

References

PMID: 1967983 by Kamps M.P., et al. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

PMID: 1967982 by Nourse J., et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.