TCF7L2 Antibodies

AND TCF7L2 ELISA kits, TCF7L2 Proteins

Many biological assays use antibodies to detect TCF7L2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TCF7L2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TCF7L2 antibodies...

We validate the specificity of these antibodies to TCF7L2 by testing them on tissues known to express TCF7L2 positively and negatively. Browse below to find the TCF7L2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TCF7L2 Infographic by Boster Bio

All TCF7L2 Products

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Product

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Specificity

Applications

Price

Anti-TCF7L2 Rabbit Monoclonal Antibody

4 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M00431
100 μl

Anti-Transcription factor 7-like 2 TCF7L2 Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$405
Cat # A00431-1
100ul

TCF7L2 Overview

Facts about Transcription factor 7-like 2.

TCF7L2 3D structure. Source: alphafold

Transcription factor 7-like 2 (TCF7L2)

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter at a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence.

Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the existence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1.

Gene Information

Human
Gene Name:	TCF7L2
Uniprot:	Q9NQB0
Entrez:	6934

Family

Belongs to:

TCF/LEF family

Alternative Names

HMG box transcription factor 4; hTCF-4; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell factor-4 variant E; T-cell factor-4 variant H; T-cell factor-4 variant I; T-cell factor-4 variant J; T-cell factor-4 variant K; T-cell factor-4 variant L; T-cell factor-4 variant M; T-cell factor-4 variant X2; T-cell-specific transcription factor 4; TCF-4T-cell factor-4 variant F; TCF4T-cell factor-4 variant G; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2

Molecular Weight

Mass (kDA):
67.919 kDA

Genomic Context


Human

Location:	10q25.2-q25.3
Sequence:	10; NC_000010.11 (112950247..113167678)

Tissue Specificity

Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.

Subcellular Localizations

Nucleus, PML body. Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Malignant Neoplasms
Neoplasms
Colorectal Cancer
Insulin Resistance
Obesity
Colorectal Neoplasms
Malignant Tumor Of Colon
Carcinoma
Cell Transformation, Neoplastic
Colonic Neoplasms
Adenomatous Polyposis Coli

Polyposis
Cholangiocarcinoma
Insulin Sensitivity
Carcinogenesis
Dysequilibrium Syndrome
Impaired Glucose Tolerance
Adenocarcinoma

Interacting Proteins

CTNNB1
DAXX
HIC1
RUNX3
TNIK

XRCC6

Pathways

Secretion
Insulin Secretion
Pathogenesis
Cell Proliferation
Glucose Homeostasis
Localization
Cell Cycle
Cell Differentiation
Cell Growth
Regeneration
Cell Development
Cell Death
Transport

Angiogenesis
Rna Interference
Cell Migration
Exocytosis
Cell-cell Adhesion
Mismatch Repair
Oligodendrocyte Development

PTMs

Phosphorylation
Acetylation
Methylation
Cleavage
Glycosylation

Ubiquitination
Dephosphorylation
Sumoylation
Amidation
Oxidation

Palmitoylation

Research Areas

Signal Transduction
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCF7L2

References

PMID: 9065401 by Korinek V., et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.

PMID: 10919662 by Duval A., et al. The human T cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines.