TBC1D5 Antibodies

AND TBC1D5 ELISA kits, TBC1D5 Proteins

Many biological assays use antibodies to detect TBC1D5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBC1D5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBC1D5 antibodies...

We validate the specificity of these antibodies to TBC1D5 by testing them on tissues known to express TBC1D5 positively and negatively. Browse below to find the TBC1D5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TBC1D5 Infographic by Boster Bio

All TBC1D5 Products

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Specificity

Applications

Price

TBC1D5 (NM_001134380) Human Recombinant Protein

$1249
Cat # PROTQ92609
20 µg

TBC1D5 (NM_014744) Human Over-expression Lysate

Human

$628
Cat # LS009779
100 µg

TBC1D5 Overview

Facts about TBC1 domain family member 5.

TBC1D5 3D structure. Source: alphafold

TBC1 domain family member 5 (TBC1D5)

May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A.

Can displace RAB7A and retromer CSC subcomplex in the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity.

Gene Information

Human
Gene Name:	TBC1D5
Uniprot:	Q92609
Entrez:	9779

Family

Belongs to:

No superfamily

Alternative Names

TBC1 domain family, member 5

Molecular Weight

Mass (kDA):
89.004 kDA

Genomic Context


Human

Location:	3p24.3
Sequence:	3; NC_000003.12 (17157162..17742739, complement)

Subcellular Localizations

Endosome membrane. Cytoplasmic vesicle, autophagosome. During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes.

Diseases

Malignant Neoplasms
Charcot-marie-tooth Disease
Neoplasms
Peripheral Neuropathy
Malignant Neoplasm Of Breast
Mammary Neoplasms
Aneuploidy

Neoplasm Invasiveness

Interacting Proteins

AP2M1
ATXN1
GABARAPL2
VPS29
Vps29

VPS35

Pathways

Transport
Localization
Chromatin Remodeling
Autophagy
Secretion

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBC1D5

References

PMID: 19531583 by Seaman M.N., et al. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.

PMID: 20923837 by Harbour M.E., et al. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.