PIEZO1 Antibodies

AND PIEZO1 ELISA kits, PIEZO1 Proteins

Many biological assays use antibodies to detect PIEZO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIEZO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIEZO1 antibodies...

We validate the specificity of these antibodies to PIEZO1 by testing them on tissues known to express PIEZO1 positively and negatively. Browse below to find the PIEZO1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN4 Next: RNF144A

PIEZO1 Infographic by Boster Bio

All PIEZO1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

PIEZO1 Overview

Facts about Piezo-type mechanosensitive ion channel component 1.

PIEZO1 3D structure. Source: alphafold

Piezo-type mechanosensitive ion channel component 1 (PIEZO1)

Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium.

Plays a vital role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruiting to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the discovery of intraluminal pressure changes and to urine flow sensing.

Gene Information

Human
Gene Name:	PIEZO1
Uniprot:	Q92508
Entrez:	9780

Family

Belongs to:

PIEZO (TC 1.A.75) family

Alternative Names

FAM38A; member A; membrane protein induced by beta-amyloid treatment; Mib; piezo-type mechanosensitive ion channel component 1

Molecular Weight

Mass (kDA):
286.79 kDA

Genomic Context


Human

Location:	16q24.3
Sequence:	16; NC_000016.10 (88715338..88785220, complement)

Tissue Specificity

Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level).

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane; Multi-pass membrane protein. Cell projection, lamellipodium membrane. In erythrocytes, located in the plasma membrane (PubMed:22529292, PubMed:23479567). Accumulates at the leading apical lamellipodia of endothelial cells in response to shear stress (PubMed:25119035).

Diseases

Neoplasms
Malignant Neoplasms
Pain
Neuroblastoma
Hereditary Diseases
Tissue Adhesions
Xerocytosis
Carcinoma, Transitional Cell
Hydrops Fetalis
Neoplasm Metastasis
Metastatic Malignant Neoplasm To The Lung
Dehydration

Carcinoma, Papillary
Malignant Neoplasm Of Lung
Carcinoma
Cardiovascular Diseases
Edema
Encephalitis
Recurrence (disease Attribute)

Pathways

Cell Adhesion
Cell Division
Cell Migration
Cell Death
Mitosis
Integrin Activation
Cell-matrix Adhesion

Proprioception
Rna Interference

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

Research Areas

Alzheimers Research
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIEZO1

References

PMID: 16854388 by Satoh K., et al. A novel membrane protein, encoded by the gene covering KIAA0233, is transcriptionally induced in senile plaque-associated astrocytes.

PMID: 22529292 by Zarychanski R., et al. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis.