TAOK2 Antibodies

AND TAOK2 ELISA kits, TAOK2 Proteins

Many biological assays use antibodies to detect TAOK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TAOK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TAOK2 antibodies...

We validate the specificity of these antibodies to TAOK2 by testing them on tissues known to express TAOK2 positively and negatively. Browse below to find the TAOK2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TAOK2 Infographic by Boster Bio

All TAOK2 Products

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Specificity

Applications

Price

Anti-Phospho-TAO2 (Ser181) TAOK2 Antibody

3 Q&As

Human, Mouse, Rat

$481
Cat # P07466
100 µl

Anti-TAOK2 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A07466
100ul

TAOK2 (NM_004783) Human Over-expression Lysate

Human

$960
Cat # LS009344
100 µg

TAOK2 Overview

Facts about Serine/threonine-protein kinase TAO2.

TAOK2 3D structure. Source: alphafold

Serine/threonine-protein kinase TAO2 (TAOK2)

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, triggered MAPK8, MAP2K3, MAP2K6 and tubulins.

Activates the MAPK14/p38 MAPK signaling pathway through the particular activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, such as cell contraction, membrane blebbing and apoptotic bodies formation.

Gene Information

Human
Gene Name:	TAOK2
Uniprot:	Q9UL54
Entrez:	9344

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; KFC-C; KIAA0881PSK-1; Kinase from chicken homolog C; MAP3K17; MAP3K17PSK1-BETA; Prostate-derived STE20-like kinase 1; PSK1; PSK1EC 2.7.11.1; PSKhKFC-C; serine/threonine-protein kinase TAO2; TAO kinase 2; TAO1; TAO2; TAO2prostate derived STE20-like kinase PSK; TAOK2; Thousand and one amino acid protein 2; thousand and one amino acid protein kinase

Molecular Weight

Mass (kDA):
138.251 kDA

Genomic Context


Human

Location:	16p11.2
Sequence:	16; NC_000016.10 (29973868..29992261)

Tissue Specificity

Ubiquitously expressed, with a higher level of expression in testis and brain.

Subcellular Localizations

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.; [Isoform 2]: Cell projection, dendrite. In dendrites, colocalizes with PCDH8.

Diseases

Child Development Disorders, Pervasive
Autistic Disorder
Autism Spectrum Disorders

Pathways

Dendrite Morphogenesis
Dendrite Development

PTMs

Phosphoprotein

Research Areas

Apoptosis
Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TAOK2

References

PMID: 10660600 by Moore T.M., et al. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation.

PMID: 13679851 by Yustein J.T., et al. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.