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- Table of Contents
Facts about Heterogeneous nuclear ribonucleoprotein Q.
Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is a portion of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself.
Human | |
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Gene Name: | SYNCRIP |
Uniprot: | O60506 |
Entrez: | 10492 |
Belongs to: |
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No superfamily |
dJ3J17.2; Glycine- and tyrosine-rich RNA-binding protein; GRYRBP; GRY-RBPNS1-associated protein 1; heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; hnRNP-Q; HNRPQ; HNRPQ1; NSAP1FLJ31626; PP68; synaptotagmin binding, cytoplasmic RNA interacting protein; Synaptotagmin-binding, cytoplasmic RNA-interacting protein
Mass (kDA):
69.603 kDA
Human | |
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Location: | 6q14.3 |
Sequence: | 6; NC_000006.12 (85607784..85643862, complement) |
Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.
Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity).; [Isoform 1]: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm.
PMID: 9847309 by Harris C.E., et al. A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice.
PMID: 11574476 by Mourelatos Z., et al. SMN interacts with a novel family of hnRNP and spliceosomal proteins.