Sarcospan Antibodies

AND SSPN ELISA kits, Sarcospan Proteins

Many biological assays use antibodies to detect Sarcospan, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sarcospan in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sarcospan antibodies...

We validate the specificity of these antibodies to Sarcospan by testing them on tissues known to express SSPN positively and negatively. Browse below to find the SSPN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SSPN Infographic by Boster Bio

All SSPN Products

Product

Figures

Specificity

Applications

Price

SSPN (NM_001135823) Human Recombinant Protein

$1249
Cat # PROTQ14714
20 µg

SSPN (NM_005086) Human Over-expression Lysate

Human

$628
Cat # LS008082
100 µg

SSPN Overview

Facts about Sarcospan.

SSPN 3D structure. Source: alphafold

Sarcospan (SSPN)

Part of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially partners with the sarcoglycan subcomplex of the DGC.

Gene Information

Human
Gene Name:	SSPN
Uniprot:	Q14714
Entrez:	8082

Family

Belongs to:

No superfamily

Alternative Names

DAGA5; Kirsten-ras associated; Kirsten-ras-associated protein; KRAGNSPN; K-ras oncogene-associated protein; microspan; nanospan; sarcospan (Kras oncogene-associated gene); sarcospan; SPN1; SPN2

Molecular Weight

Mass (kDA):
26.618 kDA

Genomic Context


Human

Location:	12p12.1
Sequence:	12; NC_000012.12 (26121951..26234777)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions.

Diseases

Muscular Dystrophy
Dystrophy
Muscular Dystrophies, Limb-girdle
Muscular Dystrophy, Duchenne
Muscular Dystrophy, Animal
Cardiomyopathies
Congenital Muscular Dystrophy (disorder)
Fibrosis
Neoplasms
Nervousness
Lung Neoplasms
Sarcoglycanopathies
Lung Diseases

Acquired Kyphosis
Carcinoma
Non-small Cell Lung Carcinoma
Severe Autosomal Recessive Muscular Dystrophy Of Childhood - North African Type (disorder)
Myocardial Necrosis
Muscle Necrosis
Adrenal Carcinoma

Pathways

Localization
Pathogenesis
Regeneration
Glycosylation
Transport
Spore Germination
Brain Development
Protein Transport
Sporulation
Limb Development

Ion Homeostasis
Cell Death
Cell Differentiation
Germination
Extracellular Matrix Assembly

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SSPN

References

PMID: 9395445 by Crosbie R.H., et al. Sarcospan, the 25-kDa transmembrane component of the dystrophin- glycoprotein complex.

PMID: 8661122 by Heighway J., et al. Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG.