KMT2D Antibodies

AND KMT2D ELISA kits, KMT2D Proteins

Many biological assays use antibodies to detect KMT2D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMT2D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMT2D antibodies...

We validate the specificity of these antibodies to KMT2D by testing them on tissues known to express KMT2D positively and negatively. Browse below to find the KMT2D antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KMT2D Infographic by Boster Bio

All KMT2D Products

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Anti-MLL2 KMT2D Antibody

Human

IHC

$380
Cat # A00488
100ul

KMT2D Overview

Facts about Histone-lysine N-methyltransferase 2D.

Histone-lysine N-methyltransferase 2D (KMT2D)

Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me).

H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.

Gene Information

Human
Gene Name:	KMT2D
Uniprot:	O14686
Entrez:	8085

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

Histone-lysine N-methyltransferase 2D

Molecular Weight

Mass (kDA):
593.389 kDA

Genomic Context


Human

Location:	12q13.12
Sequence:	12; NC_000012.12 (49018975..49060884, complement)

Tissue Specificity

Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.

Subcellular Localizations

Nucleus.

Diseases

Kabuki syndrome 1 (KABUK1)

Interacting Proteins

AR
ESR1

PTMs

Acetylation
Isopeptide bond

Methylation
Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMT2D

References

PMID: 9247308 by Prasad R., et al. Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.

PMID: 12482968 by Goo Y.-H., et al. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.