SMPD4 Antibodies

AND SMPD4 ELISA kits, SMPD4 Proteins

Many biological assays use antibodies to detect SMPD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMPD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMPD4 antibodies...

We validate the specificity of these antibodies to SMPD4 by testing them on tissues known to express SMPD4 positively and negatively. Browse below to find the SMPD4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMPD4 Infographic by Boster Bio

All SMPD4 Products

Product

Figures

Specificity

Applications

Price

Anti-SMPD4 Antibody

Human, Mouse

IF, ICC, WB

$405
Cat # A12855
100ul

SMPD4 (NM_017951) Human Over-expression Lysate

Human

$960
Cat # LS055627
100 µg

SMPD4 Overview

Facts about Sphingomyelin phosphodiesterase 4.

SMPD4 3D structure. Source: alphafold

Sphingomyelin phosphodiesterase 4 (SMPD4)

Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924).

Gene Information

Human
Gene Name:	SMPD4
Uniprot:	Q9NXE4
Entrez:	55627

Family

Belongs to:

No superfamily

Alternative Names

KIAA1418; NET13; Neutral Sphingomyelinase 3; Neutral Sphingomyelinase III; NSMASE3; NSMASE-3; SKNY Protein; Sphingomyelin Phosphodiesterase 4; Sphingomyelin Phosphodiesterase 4, Neutral Membrane (Neutral Sphingomyelinase-3)

Molecular Weight

Mass (kDA):
97.81 kDA

Genomic Context


Human

Location:	2q21.1
Sequence:	2; NC_000002.12 (130151392..130181757, complement)

Tissue Specificity

Widely expressed, with highest levels in heart and skeletal muscle.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Nucleus envelope.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMPD4

References

PMID: 18505924 by Corcoran C.A., et al. Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress- regulated gene that is deregulated in human malignancies.

PMID: 16517606 by Krut O., et al. Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein.