Proline-rich nuclear receptor coactivator 2 (Pnrc2)

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (By similarity). May act by targeting the NMD machinery into the P-body and recruitment the decapping machinery to aberrant mRNAs (By similarity).

Required for UPF1/RENT1 localization into the P-body (By similarity). Plays a role in glucocorticoid receptor- mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent way when it's bound to the 5' UTR of target mRNAs and recruitment the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity).