Zinc transporter 8 Antibodies

AND SLC30A8 ELISA kits, Zinc transporter 8 Proteins

Many biological assays use antibodies to detect Zinc transporter 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc transporter 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc transporter 8 antibodies...

We validate the specificity of these antibodies to Zinc transporter 8 by testing them on tissues known to express SLC30A8 positively and negatively. Browse below to find the SLC30A8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC30A8 Infographic by Boster Bio

All SLC30A8 Products

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Anti-Zinc transporter 8 SLC30A8 Antibody

Human

ELISA, IF, IHC-P, WB

$449
Cat # A01310
0.1 mg

Zinc transporter 8 (SLC30A8) (NM_173851) Human Over-expression Lysate

Human

$628
Cat # LS169026
100 µg

SLC30A8 Overview

Facts about Zinc transporter 8.

SLC30A8 3D structure. Source: alphafold

Zinc transporter 8 (SLC30A8)

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a significant component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells.

Gene Information

Human
Gene Name:	SLC30A8
Uniprot:	Q8IWU4
Entrez:	169026

Family

Belongs to:

cation diffusion facilitator (CDF) transporter (TC 2.A.4) family

Alternative Names

SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; zinc transporter 8; zinc transporter ZnT-8; ZnT8; ZnT-8; ZNT8ZnT-8

Molecular Weight

Mass (kDA):
40.755 kDA

Genomic Context


Human

Location:	8q24.11
Sequence:	8; NC_000008.11 (116950217..117176714)

Tissue Specificity

In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Associated with insulin and glucagon secretory granules.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Diabetes Mellitus, Insulin-dependent
Autoimmunity
Insulin Resistance
Obesity
Insulin Sensitivity
Autoimmune Reaction
Impaired Glucose Tolerance
Hyperglycemia
Cholangiocarcinoma
Prediabetes Syndrome

Diabetes, Autoimmune
Dysequilibrium Syndrome
Complications Of Diabetes Mellitus
Autoimmune Diseases
Insulinoma
Gestational Diabetes
Atherosclerosis

Interacting Proteins

CREB3L1

Pathways

Secretion
Insulin Secretion
Pathogenesis
Glucose Homeostasis
Transport
Insulin Processing
Translation
Glucagon Secretion
Secretory Pathway
Cell Development
Localization
Regeneration
Stem Cell Differentiation

Immune Response
Hypersensitivity
Flight
Cell Cycle
Cell Differentiation
Exocytosis
Hormone Secretion

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC30A8

References

PMID: 15331542 by Chimienti F., et al. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.

PMID: 16158222 by Chimienti F., et al. ZnT-8, a pancreatic beta-cell-specific zinc transporter.