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SLAM family member 7 Antibodies
AND SLAMF7 ELISA kits, SLAM family member 7 Proteins
Many biological assays use antibodies to detect SLAM family member 7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLAM family member 7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLAM family member 7 antibodies...
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SLAMF7 Infographic by Boster Bio
All SLAMF7 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK2012
96 wells/kit, with removable strips.
Cat # EK2012
96 wells/kit, with removable strips.
Human
Flow Cytometry, IHC, WB
$523
Cat # M04083
100 µl
Cat # M04083
100 µl
SLAMF7 Overview
Facts about SLAM family member 7.
SLAM family member 7 (SLAMF7)
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and are involved in the regulation and interconnection of both innate and adaptive immune reaction.
Tasks are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation via a SH2D1A-independent extracellular signal- regulated ERK-mediated pathway (PubMed:11698418).
Gene Information
| Human | |
|---|---|
| Gene Name: | SLAMF7 |
| Uniprot: | Q9NQ25 |
| Entrez: | 57823 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
19A; CD2 subset 1; CD2-like receptor activating cytotoxic cells; CD319 antigen; CD319; CRACC; CRACCCD2-like receptor-activating cytotoxic cells; CS119A24 protein; Membrane protein FOAP-12; novel LY9 (lymphocyte antigen 9) like protein; Novel Ly9; Protein 19A; SLAM family member 7; SLAMF7
Molecular Weight
Mass (kDA):
37.421 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (160739057..160754821) |
Tissue Specificity
Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Multiple Myeloma
- Tissue Adhesions
- Autoimmune Diseases
- Autoimmune Reaction
- X-linked Lymphoproliferative Disorders
- Lymphoproliferative Disorders
- Malignant Neoplasms
- Neoplasms
- Lupus Erythematosus, Systemic
- Sclerosis
- Polyps
- Carcinoma
- Plasmacytoma
Pathways
- Immune Response
- Lymphocyte Activation
- Cell Adhesion
- Cell Activation
- Secretion
- Cell Proliferation
- B Cell Proliferation
- Antibody-dependent Cellular Cytotoxicity
- Transport
- Germinal Center Formation
- Cell Killing
- Cytokine Secretion
- Leukocyte Differentiation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLAMF7
bosterbio.com/bosterbio-gene-info-cards/SLAMF7
References
PMID: 11220635 by Boles K.S., et al. Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily.
PMID: 11698418 by Bouchon A., et al. Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family.