SYTL2 Antibodies

AND SYTL2 ELISA kits, SYTL2 Proteins

Many biological assays use antibodies to detect SYTL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SYTL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SYTL2 antibodies...

We validate the specificity of these antibodies to SYTL2 by testing them on tissues known to express SYTL2 positively and negatively. Browse below to find the SYTL2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SYTL2 Infographic by Boster Bio

All SYTL2 Products

Product

Figures

Specificity

Applications

Price

SYTL2 (NM_206929) Human Recombinant Protein

$1249
Cat # PROTQ9HCH5
20 µg

SYTL2 (NM_032943) Human Over-expression Lysate

Human

$960
Cat # LS054843
100 µg

Anti-SLP2/SYTL2 Antibody Picoband™

Human

ELISA, WB

$370
Cat # A08255-1
100 µg/vial

SYTL2 Overview

Facts about Synaptotagmin-like protein 2.

SYTL2 3D structure. Source: alphafold

Synaptotagmin-like protein 2 (SYTL2)

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It's necessary for cytotoxic granule docking at the immunologic synapse.

Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.

Gene Information

Human
Gene Name:	SYTL2
Uniprot:	Q9HCH5
Entrez:	54843

Family

Belongs to:

No superfamily

Alternative Names

Synaptotagmin-like protein 2

Molecular Weight

Mass (kDA):
104.93 kDA

Genomic Context


Human

Location:	11q14.1
Sequence:	11; NC_000011.10 (85694221..85811182, complement)

Tissue Specificity

Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.

Subcellular Localizations

[Isoform 1]: Cytoplasm. Cell membrane. Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.; [Isoform 4]: Cell membrane. In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.

Interacting Proteins

PPP1CA
Rab27a

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SYTL2

References

PMID: 18812475 by Menasche G., et al. A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates in cytotoxic granule secretion.

PMID: 17182843 by Yu M., et al. Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain.