Synaptojanin-2 Antibodies

AND SYNJ2 ELISA kits, Synaptojanin-2 Proteins

Many biological assays use antibodies to detect Synaptojanin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Synaptojanin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Synaptojanin-2 antibodies...

We validate the specificity of these antibodies to Synaptojanin-2 by testing them on tissues known to express SYNJ2 positively and negatively. Browse below to find the SYNJ2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SYNJ2 Infographic by Boster Bio

All SYNJ2 Products

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Synaptojanin 2 (SYNJ2) (NM_003898) Human Recombinant Protein

$1062
Cat # PROTO15056
20 µg

Synaptojanin 2 (SYNJ2) (NM_003898) Human Over-expression Lysate

Human

$960
Cat # LS008871
100 µg

Anti-SYNJ2 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A08206-1
100 µg/vial

SYNJ2 Overview

Facts about Synaptojanin-2.

SYNJ2 3D structure. Source: alphafold

Synaptojanin-2 (SYNJ2)

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

Gene Information

Human
Gene Name:	SYNJ2
Uniprot:	O15056
Entrez:	8871

Family

Belongs to:

synaptojanin family

Alternative Names

EC 3.1.3.36; inositol phosphate 5'-phosphatase 2; INPP5H; KIAA0348MGC44422; Synaptic inositol-14,5-trisphosphate 5-phosphatase 2; synaptojanin 2; synaptojanin-2

Molecular Weight

Mass (kDA):
165.538 kDA

Genomic Context


Human

Location:	6q25.3
Sequence:	6; NC_000006.12 (157981856..158099176)

Subcellular Localizations

Cytoplasm. Cell membrane. Membrane raft. Cell junction, synapse, presynapse. Cytoplasm, cytoskeleton. Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340).

Diseases

Neoplasms
Malignant Neoplasms
Nervous System Neoplasms
Cell Invasion
Malignant Neoplasm Of Prostate
Central Nervous System Neoplasms
Anxiety Disorders
Depressive Symptom
Pediatric Neoplasm
Cytopathic Effect
Personality Disorders
Sterility

Brain Neoplasms
Ependymoma
Prostatic Neoplasms
Nervousness
Depressive Disorder
Sensorineural Hearing Loss (disorder)
Impaired Cognition

Interacting Proteins

GRB2
NCK1
SH3KBP1

Pathways

Clathrin-mediated Endocytosis
Cell Death
Cognition
Endocytosis
Mating

PTMs

Phosphorylation

Research Areas

Neuronal Cell Markers
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SYNJ2

References

PMID: 11084340 by Malecz N., et al. Synaptojanin 2, a novel Rac1 effector that regulates clathrin- mediated endocytosis.

PMID: 11498538 by Nemoto Y., et al. Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals.