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- Table of Contents
Facts about Rho guanine nucleotide exchange factor 7.
Promotes targeting of RAC1 to focal adhesions (By similarity). May be a positive regulator of apoptosis.
Human | |
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Gene Name: | ARHGEF7 |
Uniprot: | Q14155 |
Entrez: | 8874 |
Belongs to: |
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No superfamily |
Beta-Pix; COOL1COOL-1; DKFZp686C12170; DKFZp761K1021; guanine nucleotide exchange factor 7; KIAA0142KIAA0412; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPRBETA-PIX; PAK3; PAK3BP; PIXBPAK-interacting exchange factor beta; Rho guanine nucleotide exchange factor (GEF) 7; rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
Mass (kDA):
90.012 kDA
Human | |
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Location: | 13q34 |
Sequence: | 13; NC_000013.11 (111114619..111305734) |
Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Detected at cell adhesions. A small proportion is detected at focal adhesions.
PMID: 9726964 by Bagrodia S., et al. A novel regulator of p21-activated kinases.
PMID: 15491607 by Homma K., et al. Alternative splice variants encoding unstable protein domains exist in the human brain.