SUN domain-containing protein 3 (Sun3)

As a probable part of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the link between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an essential role in the transmission of mechanical forces across the nuclear envelope and in atomic movement and positioning.

May be involved in nuclear remodeling during sperm head formation in spermatogenenis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures like the manchette.