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, No Gclids
SUN2 Antibodies
AND SUN2 ELISA kits, SUN2 Proteins
Many biological assays use antibodies to detect SUN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SUN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SUN2 antibodies...
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SUN2 Infographic by Boster Bio
All SUN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03291-1
100 μl/vial
Cat # M03291-1
100 μl/vial
SUN2 Overview
Facts about SUN domain-containing protein 2.
SUN domain-containing protein 2 (SUN2)
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the Link between the nuclear lamina and the cytoskeleton.
The nucleocytoplasmic interactions created by the LINC complex play an essential role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.Especially, SYNE2 and SUN2 build in arrays of transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow through actin- dependent nuclear movement. Required for interkinetic nuclear migration (INM) and necessary for nucleokinesis and centrosome- nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | SUN2 |
| Uniprot: | Q9UH99 |
| Entrez: | 25777 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FRIGG; KIAA0668; MGC133055; MGC133056; nuclear envelope protein; Protein unc-84 homolog B; Rab5-interacting protein; rab5IP; Sad1 and UNC84 domain containing 2; Sad1 unc-84 domain protein 2; Sad1/unc-84 protein-like 2; SUN domain-containing protein 2; unc-84 homolog B (C. elegans); unc-84 homolog B; UNC84B
Molecular Weight
Mass (kDA):
80.311 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (38734727..38756014, complement) |
Tissue Specificity
Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.
Subcellular Localizations
Nucleus inner membrane; Single-pass type II membrane protein. Nucleus envelope. Endosome membrane; Single-pass type II membrane protein.
Diseases
- Muscular Dystrophy
- Muscular Dystrophy, Emery-dreifuss
- Dystrophy
- Congenital Heart Defects
- Cardiomyopathies
- Progeria
- Myopathy
- Muscular Atrophy
- Chikungunya Virus Infection
- Coronary Heart Disease
- Weakness
- Infectious Mononucleosis
Interacting Proteins
- COPB1
- EMD
- KPNA2
- LMNA
- NRM
- RAB5A
- SYNE1
- SYNE2
Pathways
- Localization
- Nuclear Migration
- Cell Migration
- Cell Cycle
- Cell Division
- Meiosis
- Prophase
- Interkinetic Nuclear Migration
- Meiotic Prophase I
- Mitosis
- Endocytosis
- Pathogenesis
- Cell Adhesion
PTMs
- Farnesylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SUN2
bosterbio.com/bosterbio-gene-info-cards/SUN2
References
PMID: 10818110 by Hoffenberg S., et al. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.
PMID: 17132086 by Wang Q., et al. Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome.