DSTYK Antibodies

AND DSTYK ELISA kits, DSTYK Proteins

Many biological assays use antibodies to detect DSTYK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DSTYK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DSTYK antibodies...

We validate the specificity of these antibodies to DSTYK by testing them on tissues known to express DSTYK positively and negatively. Browse below to find the DSTYK antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DSTYK Infographic by Boster Bio

All DSTYK Products

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RIPK5 (DSTYK) (NM_015375) Human Recombinant Protein

$1062
Cat # PROTQ6XUX3
20 µg

RIPK5 (DSTYK) (NM_015375) Human Over-expression Lysate

Human

$628
Cat # LS025778
100 µg

DSTYK Overview

Facts about Dual serine/threonine and tyrosine protein kinase.

DSTYK 3D structure. Source: alphafold

Dual serine/threonine and tyrosine protein kinase (DSTYK)

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406).

In the epidermis, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). .

Gene Information

Human
Gene Name:	DSTYK
Uniprot:	Q6XUX3
Entrez:	25778

Family

Belongs to:

protein kinase superfamily

Alternative Names

dual serine/threonine and tyrosine protein kinase; Dusty PK; Dusty protein kinase; DustyPK; KIAA0472RIP-homologous kinase; receptor interacting protein 5; receptor interacting protein kinase 5; Receptor-interacting serine/threonine-protein kinase 5; RIP5EC 2.7.12.1; RIPK5; sgK496; Sugen kinase 496

Molecular Weight

Mass (kDA):
105.206 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (205142497..205211702, complement)

Tissue Specificity

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin (PubMed:28157540).

Subcellular Localizations

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia.

Diseases

Malignant Neoplasms
Nervousness

Pathways

Induction Of Apoptosis
Cell Death
Regulation Of Signal Transduction

PTMs

Phosphorylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DSTYK

References

PMID: 17123648 by Peng J., et al. Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.

PMID: 15178406 by Zha J., et al. RIP5 is a RIP-homologous inducer of cell death.