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- Table of Contents
Facts about Small ubiquitin-related modifier 4.
Upon oxidative stress, conjugates to different anti-oxidant enzymes, chaperones, and anxiety defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity.
Human | |
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Gene Name: | SUMO4 |
Uniprot: | Q6EEV6 |
Entrez: | 387082 |
Belongs to: |
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ubiquitin family |
dJ281H8.4; IDDM5; small ubiquitin-like modifier 4 protein; Small ubiquitin-like protein 4; small ubiquitin-related modifier 4; SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 4 (yeast); SMT3H4; SUMO4; SUMO-4
Mass (kDA):
10.685 kDA
Human | |
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Location: | 6q25.1 |
Sequence: | 6; NC_000006.12 (149400262..149401278) |
Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
PMID: 15123604 by Bohren K.M., et al. A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.
PMID: 15247916 by Guo D., et al. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.