Syntaxin-17 Antibodies

AND STX17 ELISA kits, Syntaxin-17 Proteins

Many biological assays use antibodies to detect Syntaxin-17, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Syntaxin-17 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Syntaxin-17 antibodies...

We validate the specificity of these antibodies to Syntaxin-17 by testing them on tissues known to express STX17 positively and negatively. Browse below to find the STX17 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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STX17 Infographic by Boster Bio

All STX17 Products

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Product

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Specificity

Applications

Price

Human STX17 Recombinant Protein

SDS-PAGE

$250
Cat # PROTP56962
Starting from 10ug

STX17 (NM_017919) Human Over-expression Lysate

Human

$628
Cat # LS055014
100 µg

STX17 Overview

Facts about Syntaxin-17.

STX17 3D structure. Source: alphafold

Syntaxin-17 (STX17)

SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complicated, an extended, parallel four alpha-helical bundle that drives membrane fusion.

STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway in which it might keep the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).

Gene Information

Human
Gene Name:	STX17
Uniprot:	P56962
Entrez:	55014

Family

Belongs to:

syntaxin family

Alternative Names

MGC102796; MGC126613; MGC126615; syntaxin 17; syntaxin-17

Molecular Weight

Mass (kDA):
33.403 kDA

Genomic Context


Human

Location:	9q31.1
Sequence:	9; NC_000009.12 (99906654..99974541)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytosol. Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). May also localize to the mitochondria according to PubMed:23217709.

Diseases

Melanoma
Hypopigmentation Disorder
Horse Diseases
Skin Neoplasms
Malignant Paraganglionic Neoplasm
Autoimmune Diseases
Autoimmune Reaction
Alopecia Areata
Autoimmunity
Germline Mutation Abnormality
Liver Carcinoma
Facial Neoplasms
Crest Syndrome

Carcinoma
Malignant Neoplasms
Carcinoma, Pancreatic Ductal
Cutaneous Melanoma
Cytomegalovirus Infections
Pancreatic Neoplasm
Liver Neoplasms

Interacting Proteins

SNAP29
Vamp7
VAMP8
VPS16
VPS33A

Pathways

Pathogenesis
Transport
Cell Cycle
Pigmentation
Oocyte Maturation
Membrane Fusion

Localization

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STX17

References

PMID: 21545355 by Muppirala M., et al. Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi.

PMID: 23006999 by Muppirala M., et al. Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway.