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- Table of Contents
Facts about Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase.
Involved in the biosynthesis of ganglioside GD1A from GM1B.
Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids.Prefers glycoproteins into glycolipids. .
Mouse | |
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Gene Name: | St6galnac4 |
Uniprot: | Q9R2B6 |
Entrez: | 20448 |
Belongs to: |
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glycosyltransferase 29 family |
EC 2.4.99; EC 2.4.99.7; NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase IV; NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase; Sialyltransferase 3C; Sialyltransferase 7D; sialyltransferase 7D((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminidealpha-2,6-sialyltransferase); SIAT3C; SIAT3-C; SIAT3C6-sialyltransferasealpha2,6-sialyltransferase; SIAT7D; SIAT7-D; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminidealpha-2,6-sialyltransferase 4; ST6GalNAc IV; ST6GALNAC4; ST6GalNAcIV
Mass (kDA):
40.773 kDA
Mouse | |
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Location: | 2|2 B |
Sequence: | 2; |
High expression in brain and colon and to a lesser extent in lung, heart, kidney, spleen and thymus.
PMID: 10207017 by Lee Y.-C., et al. Molecular cloning and functional expression of two members of mouse NeuAc-alpha-2,3Gal-beta-1,3GalNAc GalNAc-alpha2,6-sialyltransferase family, ST6GalNAc III and IV.
PMID: 10731711 by Takashima S., et al. Comparative analysis of the genomic structures and promoter activities of mouse Siaa2,3Galb1,3GalNAc GalNAca2,6-sialyltransferase genes (ST6GalNAc III and IV): characterization of their Sp1 binding.