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Ssx2ip Antibodies
AND Ssx2ip ELISA kits, Ssx2ip Proteins
Many biological assays use antibodies to detect Ssx2ip, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ssx2ip in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ssx2ip antibodies...
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Ssx2ip Infographic by Boster Bio
All Ssx2ip Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M05918
100 µl
Cat # M05918
100 µl
Human, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A05918-1
100 µg/vial
Cat # A05918-1
100 µg/vial
Ssx2ip Overview
Facts about Afadin- and alpha-actinin-binding protein.
Afadin- and alpha-actinin-binding protein (Ssx2ip)
Belongs to an adhesion system, which plays a role in the business of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton in AJs through afadin and alpha-actinin (PubMed:12446711).
Acts as a centrosome maturation factor, probably by keeping the integrity of the pericentriolar material and proper microtubule nucleation in mitotic spindle poles. The function seems to implicate at least part WRAP73; the SSX2IP:WRAP73 complex is suggested to act as regulator of spindle anchoring in the mitotic centrosome (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ssx2ip |
| Uniprot: | Q8VC66 |
| Entrez: | 99167 |
Family
| Belongs to: |
|---|
| ADIP family |
Alternative Names
ADIP; afadin- and alpha-actinin-binding protein; Afadin DIL domain-interacting protein; FLJ10848; KIAA0923; MGC75026; SSX2-interacting protein; synovial sarcoma, X breakpoint 2 interacting protein
Molecular Weight
Mass (kDA):
70.956 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3|3 H2 |
| Sequence: | 3; |
Tissue Specificity
Widely expressed.
Diseases
- Myeloid Leukemia
- Leukemia
- Leukemia, Myelocytic, Acute
- Tissue Adhesions
- Malignant Neoplasms
- Synovial Sarcoma
- Sarcoma
- Melanoma
- Malignant Paraganglionic Neoplasm
Pathways
- Mitosis
- Cell-cell Adhesion
- Cell Adhesion
- Methylation
- Cell Cycle
- Dna Methylation
- Cell Growth
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ssx2ip
bosterbio.com/bosterbio-gene-info-cards/Ssx2ip
References
PMID: 12446711 by Asada M., et al. ADIP, a novel afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.
PMID: 22027834 by Fukumoto Y., et al. Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.